Water-driven ligations using cyclic amino squarates: A class of useful SN1-like reactions

Dawei Cui, Deepali Prashar, Preeti Sejwal, Yan Yeung Luk

Research output: Contribution to journalArticlepeer-review

4 Scopus citations


We report a class of water-soluble and -stable cyclic amino squarates that ligate with cysteine or lysine residues without side-products in an entirely aqueous environment. The ligations include addition-elimination reactions that are promoted by water in a way similar to SN1 reactions. The structural versatility of the reactants allows the potential recognition of selected amino acid residues on proteins.

Original languageEnglish (US)
Pages (from-to)1348-1350
Number of pages3
JournalChemical Communications
Issue number4
StatePublished - Jan 10 2011

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry


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