Vitamin B12 as a carrier for the oral delivery of insulin

Amanda K. Petrus, Anthony R. Vortherms, Timothy J. Fairchild, Robert P. Doyle

Research output: Contribution to journalArticle

53 Scopus citations

Abstract

The noninvasive delivery of insulin continues to be a major goal for the treatment of diabetes mellitus. Oral-enteric administration would make insulin delivery easier and more effective, as higher patient compliance and improved glycemic control are likely; yet the oral-enteric pathway has been unfeasible owing to insulin's susceptibility to proteolytic degradation and inefficient enteric uptake. Herein we show that a noninvasive oral delivery route for insulin is possible through the vitamin B12 uptake pathway. In diabetic rat models, insulin-B12 conjugates can significantly lower blood glucose levels when administered orally.

Original languageEnglish (US)
Pages (from-to)1717-1721
Number of pages5
JournalChemMedChem
Volume2
Issue number12
DOIs
StatePublished - Dec 10 2007

Keywords

  • Diabetes
  • Insulin
  • Oral delivery
  • Streptozotocin
  • Vitamins

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Organic Chemistry

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