Visible-light triggering of shape memory polymers to control cell morphology

Shelby L. Buffington, Johnson Agyapong, José F.waimin, Patrick T Mather, James H. Henderson

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Statement of Purpose Shape memory polymers (SMPs) are a class of smart materials that change their shape in response to an environmental stimulus. SMPs have emerged as powerful platforms to study how cells respond to precise mechanical changes and have been used to study or impact cell differentiation and migration.[1],[2] However, most SMP platforms are thermally triggered and therefore require at least temporary incubation at temperatures other than 37 °C. Ebara and colleagues have reported an SMP cell culture platform that is triggered by Near-infrared (NIR) light in the presence of cells.[3] However, since water absorbs more strongly in NIR wavelengths than in visible wavelengths, the use of NIR light increases the risk of direct hyperthermic effects for biomaterials in close proximity to or in contact with cells and tissues. The goals of this study were to design an SMP platform that responds to visible light by taking advantage of the surface plasmon resonant of silver nanoparticles, and to test the cytocompatibility and cell mecha-nobiological applications of this material system.

Original languageEnglish (US)
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
PublisherSociety for Biomaterials
Number of pages1
ISBN (Electronic)9781510883901
StatePublished - Jan 1 2019
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: Apr 3 2019Apr 6 2019

Publication series

NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume40
ISSN (Print)1526-7547

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
CountryUnited States
CitySeattle
Period4/3/194/6/19

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Biotechnology
  • Biomaterials
  • Materials Chemistry

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  • Cite this

    Buffington, S. L., Agyapong, J., F.waimin, J., Mather, P. T., & Henderson, J. H. (2019). Visible-light triggering of shape memory polymers to control cell morphology. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40). Society for Biomaterials.