TY - GEN
T1 - Vibrational and energetic analysis of sorbitol crystal forms
AU - Dierks, Teresa M.
AU - Korter, Timothy M.
N1 - Publisher Copyright:
© 2017 IEEE.
PY - 2017/10/12
Y1 - 2017/10/12
N2 - Sorbitol, a widely-used sweetener and excipient, is of great interest to the pharmaceutical and food industries. Not only is it known to exist in multiple polymorphic solid-state forms, but sorbitol is also able to cocrystallize with solvent molecules with which it can form hydrogen bonds. Here, two cocrystal forms, sorbitol-water and sorbitol-pyridine, were extensively studied using both experimental and computational techniques, and compared to the anhydrous α-sorbitol polymorph. Each solid was grown and verified using single-crystal X-ray diffraction (SC-XRD) and powder X-ray diffraction (PXRD), and then analyzed using terahertz time-domain spectroscopy (THz-TDS) and solid-state density functional theory (DFT).
AB - Sorbitol, a widely-used sweetener and excipient, is of great interest to the pharmaceutical and food industries. Not only is it known to exist in multiple polymorphic solid-state forms, but sorbitol is also able to cocrystallize with solvent molecules with which it can form hydrogen bonds. Here, two cocrystal forms, sorbitol-water and sorbitol-pyridine, were extensively studied using both experimental and computational techniques, and compared to the anhydrous α-sorbitol polymorph. Each solid was grown and verified using single-crystal X-ray diffraction (SC-XRD) and powder X-ray diffraction (PXRD), and then analyzed using terahertz time-domain spectroscopy (THz-TDS) and solid-state density functional theory (DFT).
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U2 - 10.1109/IRMMW-THz.2017.8067032
DO - 10.1109/IRMMW-THz.2017.8067032
M3 - Conference contribution
AN - SCOPUS:85033695466
T3 - International Conference on Infrared, Millimeter, and Terahertz Waves, IRMMW-THz
BT - 2017 42nd International Conference on Infrared, Millimeter, and Terahertz Waves, IRMMW-THz 2017
PB - IEEE Computer Society
T2 - 42nd International Conference on Infrared, Millimeter, and Terahertz Waves, IRMMW-THz 2017
Y2 - 27 August 2017 through 1 September 2017
ER -