Vibrational and energetic analysis of sorbitol crystal forms

Teresa M. Dierks, Timothy Michael Korter

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

Sorbitol, a widely-used sweetener and excipient, is of great interest to the pharmaceutical and food industries. Not only is it known to exist in multiple polymorphic solid-state forms, but sorbitol is also able to cocrystallize with solvent molecules with which it can form hydrogen bonds. Here, two cocrystal forms, sorbitol-water and sorbitol-pyridine, were extensively studied using both experimental and computational techniques, and compared to the anhydrous α-sorbitol polymorph. Each solid was grown and verified using single-crystal X-ray diffraction (SC-XRD) and powder X-ray diffraction (PXRD), and then analyzed using terahertz time-domain spectroscopy (THz-TDS) and solid-state density functional theory (DFT).

Original languageEnglish (US)
Title of host publication2017 42nd International Conference on Infrared, Millimeter, and Terahertz Waves, IRMMW-THz 2017
PublisherIEEE Computer Society
ISBN (Electronic)9781509060481
DOIs
StatePublished - Oct 12 2017
Event42nd International Conference on Infrared, Millimeter, and Terahertz Waves, IRMMW-THz 2017 - Cancun, Quintana Roo, Mexico
Duration: Aug 27 2017Sep 1 2017

Other

Other42nd International Conference on Infrared, Millimeter, and Terahertz Waves, IRMMW-THz 2017
CountryMexico
CityCancun, Quintana Roo
Period8/27/179/1/17

ASJC Scopus subject areas

  • Energy Engineering and Power Technology
  • Electrical and Electronic Engineering

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  • Cite this

    Dierks, T. M., & Korter, T. M. (2017). Vibrational and energetic analysis of sorbitol crystal forms. In 2017 42nd International Conference on Infrared, Millimeter, and Terahertz Waves, IRMMW-THz 2017 [8067032] IEEE Computer Society. https://doi.org/10.1109/IRMMW-THz.2017.8067032