Vascular and central hemodynamic changes following exercise-induced heat stress

Wesley K. Lefferts, Kevin S. Heffernan, Eric M. Hultquist, Patricia C. Fehling, Denise L. Smith

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


This study examined the effects of moderate exercise-induced heat stress (EIHS) on vascular function, central hemodynamic load and indices of coronary perfusion. Vascular-hemodynamic measures were collected in 12 healthy men (aged 22±3 years) pre and post 100 minutes of moderate, intermittent exercise in two randomized conditions: heat stress (HS; wearing firefighter personal protective equipment (PPE)), and no heat stress (NHS; wearing a cooling shirt and equivalent PPE weight). Aortic blood pressure, reflected wave pressure (Pb), systolic (SPTI) and diastolic pressure time-integral (DPTI), and aortic stiffness were assessed before and after each condition. SPTI was significantly greater, and DPTI and Pb were significantly lower for HS-post compared to NHS-post (p<0.05). Pulse wave velocity was not different between conditions. In conclusion, EIHS does not affect aortic stiffness, but increases indices of myocardial work and reduces indices of coronary perfusion which may be related to chronotropic responses to EIHS. The mismatch between oxygen demand and oxygen supply may increase cardiac vulnerability to ischemia during strenuous work in the heat.

Original languageEnglish (US)
Pages (from-to)222-229
Number of pages8
JournalVascular Medicine (United Kingdom)
Issue number3
StatePublished - Jun 5 2015


  • arterial stiffness
  • heat stress
  • personal protective equipment
  • pulse wave reflections
  • wave separation analysis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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