Vaginal Prostate Specific Antigen (PSA) Is a Useful Biomarker of Semen Exposure Among HIV-Infected Ugandan Women

Sarah E. Woolf-King; Winnie Muyindike; Marcia M. Hobbs; Adrine Kusasira; Robin Fatch; Nneka Emenyonu; Mallory O. Johnson; Judith A. Hahn

doi:10.1007/s10461-016-1433-7

Vaginal Prostate Specific Antigen (PSA) Is a Useful Biomarker of Semen Exposure Among HIV-Infected Ugandan Women

Sarah E. Woolf-King, Winnie Muyindike, Marcia M. Hobbs, Adrine Kusasira, Robin Fatch, Nneka Emenyonu, Mallory O. Johnson, Judith A. Hahn

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

The practical feasibility of using prostate specific antigen (PSA) as a biomarker of semen exposure was examined among HIV-infected Ugandan women. Vaginal fluids were obtained with self-collected swabs and a qualitative rapid test (ABAcard^®p30) was used to detect PSA. Trained laboratory technicians processed samples on-site and positive PSA tests were compared to self-reported unprotected vaginal sex (UVS) in the last 48 h. A total of 77 women submitted 126 samples for PSA testing at up to three study visits. Of these samples, 31 % (n = 39/126) were PSA positive, and 64 % (n = 25/39) of the positive PSA samples were accompanied by self-report of no UVS at the study visit the PSA was collected. There were no reported difficulties with specimen collection, storage, or processing. These findings provide preliminary data on high levels of misreported UVS among HIV-infected Ugandan women using practically feasible methods for PSA collection and processing.

Original language	English (US)
Pages (from-to)	2141-2146
Number of pages	6
Journal	AIDS and Behavior
Volume	21
Issue number	7
DOIs	https://doi.org/10.1007/s10461-016-1433-7
State	Published - Jul 1 2017
Externally published	Yes

Keywords

Biomarker
Condom use
HIV
Prostate specific antigen
Self-report

ASJC Scopus subject areas

Social Psychology
Public Health, Environmental and Occupational Health
Infectious Diseases

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10.1007/s10461-016-1433-7

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title = "Vaginal Prostate Specific Antigen (PSA) Is a Useful Biomarker of Semen Exposure Among HIV-Infected Ugandan Women",

abstract = "The practical feasibility of using prostate specific antigen (PSA) as a biomarker of semen exposure was examined among HIV-infected Ugandan women. Vaginal fluids were obtained with self-collected swabs and a qualitative rapid test (ABAcard{\textregistered}p30) was used to detect PSA. Trained laboratory technicians processed samples on-site and positive PSA tests were compared to self-reported unprotected vaginal sex (UVS) in the last 48 h. A total of 77 women submitted 126 samples for PSA testing at up to three study visits. Of these samples, 31 % (n = 39/126) were PSA positive, and 64 % (n = 25/39) of the positive PSA samples were accompanied by self-report of no UVS at the study visit the PSA was collected. There were no reported difficulties with specimen collection, storage, or processing. These findings provide preliminary data on high levels of misreported UVS among HIV-infected Ugandan women using practically feasible methods for PSA collection and processing.",

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author = "Woolf-King, {Sarah E.} and Winnie Muyindike and Hobbs, {Marcia M.} and Adrine Kusasira and Robin Fatch and Nneka Emenyonu and Johnson, {Mallory O.} and Hahn, {Judith A.}",

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doi = "10.1007/s10461-016-1433-7",

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AU - Woolf-King, Sarah E.

AU - Muyindike, Winnie

AU - Hobbs, Marcia M.

AU - Kusasira, Adrine

AU - Fatch, Robin

AU - Emenyonu, Nneka

AU - Johnson, Mallory O.

AU - Hahn, Judith A.

PY - 2017/7/1

Y1 - 2017/7/1

N2 - The practical feasibility of using prostate specific antigen (PSA) as a biomarker of semen exposure was examined among HIV-infected Ugandan women. Vaginal fluids were obtained with self-collected swabs and a qualitative rapid test (ABAcard®p30) was used to detect PSA. Trained laboratory technicians processed samples on-site and positive PSA tests were compared to self-reported unprotected vaginal sex (UVS) in the last 48 h. A total of 77 women submitted 126 samples for PSA testing at up to three study visits. Of these samples, 31 % (n = 39/126) were PSA positive, and 64 % (n = 25/39) of the positive PSA samples were accompanied by self-report of no UVS at the study visit the PSA was collected. There were no reported difficulties with specimen collection, storage, or processing. These findings provide preliminary data on high levels of misreported UVS among HIV-infected Ugandan women using practically feasible methods for PSA collection and processing.

AB - The practical feasibility of using prostate specific antigen (PSA) as a biomarker of semen exposure was examined among HIV-infected Ugandan women. Vaginal fluids were obtained with self-collected swabs and a qualitative rapid test (ABAcard®p30) was used to detect PSA. Trained laboratory technicians processed samples on-site and positive PSA tests were compared to self-reported unprotected vaginal sex (UVS) in the last 48 h. A total of 77 women submitted 126 samples for PSA testing at up to three study visits. Of these samples, 31 % (n = 39/126) were PSA positive, and 64 % (n = 25/39) of the positive PSA samples were accompanied by self-report of no UVS at the study visit the PSA was collected. There were no reported difficulties with specimen collection, storage, or processing. These findings provide preliminary data on high levels of misreported UVS among HIV-infected Ugandan women using practically feasible methods for PSA collection and processing.

KW - Biomarker

KW - Condom use

KW - HIV

KW - Prostate specific antigen

KW - Self-report

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Vaginal Prostate Specific Antigen (PSA) Is a Useful Biomarker of Semen Exposure Among HIV-Infected Ugandan Women

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Keywords

ASJC Scopus subject areas

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