Abstract
This work reports the use of water as a solvent to facilitate an efficient syntheses of amino acid-derivatized cyclobutenone. Kinetics studies in different solvents reveals that high dielectric constants of the solvents are the primary attribute for the high yielding and fast rate for this reaction. This class of substitution reactions in water also proceeds efficiently with a wide range of amino acids.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 2128-2131 |
| Number of pages | 4 |
| Journal | Tetrahedron Letters |
| Volume | 49 |
| Issue number | 13 |
| DOIs | |
| State | Published - Mar 24 2008 |
ASJC Scopus subject areas
- Biochemistry
- Drug Discovery
- Organic Chemistry
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Cite this
Li, J., Han, Y., Freedman, T. B., Zhu, S., Kerwood, D. J., & Luk, Y. Y. (2008). Utilizing the high dielectric constant of water: efficient synthesis of amino acid-derivatized cyclobutenones. Tetrahedron Letters, 49(13), 2128-2131. https://doi.org/10.1016/j.tetlet.2008.01.121