Tuning oligonucleotide derived nanoparticle assembly

Mathew M Maye, Dmytro Nykypanchuk, Daniel Van Der Lelie, Oleg Gang

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A study designed to enhance the efficiency of self-assembly in nanoparticle-DNA systems through tailoring of oligonucleotide structure is discussed. A set of 10-nm gold nanoparticles modified with complimentary 30- base oligonucleotides building blocks was used as a model system. The assembly progression and nanostructure growth was characterized in-situ by monitoring the characteristic surface plasmon resonance band of gold nanoparticles with uv-visible spectrophotometry. The assembly kinetics and nanostructure growth were enhanced by modifying the surface bound oligonucleotide via partial duplex formation and DNA tailoring. The observed effect is attributed to the increased persistence length of the surface bound oligonucleotide, which reduces steric limitations due to coiling and base pair coordination to the gold interface.

Original languageEnglish (US)
Title of host publication3rd Conference on Foundations of Nanoscience: Self-Assembled Architectures and Devices, FNANO 2006
Pages298-302
Number of pages5
StatePublished - 2006
Externally publishedYes
Event3rd Conference on Foundations of Nanoscience: Self-Assembled Architectures and Devices, FNANO 2006 - Snowbird, UT, United States
Duration: Apr 23 2006Apr 27 2006

Other

Other3rd Conference on Foundations of Nanoscience: Self-Assembled Architectures and Devices, FNANO 2006
CountryUnited States
CitySnowbird, UT
Period4/23/064/27/06

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ASJC Scopus subject areas

  • Hardware and Architecture
  • Electrical and Electronic Engineering

Cite this

Maye, M. M., Nykypanchuk, D., Van Der Lelie, D., & Gang, O. (2006). Tuning oligonucleotide derived nanoparticle assembly. In 3rd Conference on Foundations of Nanoscience: Self-Assembled Architectures and Devices, FNANO 2006 (pp. 298-302)