Abstract
A study designed to enhance the efficiency of self-assembly in nanoparticle-DNA systems through tailoring of oligonucleotide structure is discussed. A set of 10-nm gold nanoparticles modified with complimentary 30- base oligonucleotides building blocks was used as a model system. The assembly progression and nanostructure growth was characterized in-situ by monitoring the characteristic surface plasmon resonance band of gold nanoparticles with uv-visible spectrophotometry. The assembly kinetics and nanostructure growth were enhanced by modifying the surface bound oligonucleotide via partial duplex formation and DNA tailoring. The observed effect is attributed to the increased persistence length of the surface bound oligonucleotide, which reduces steric limitations due to coiling and base pair coordination to the gold interface.
Original language | English (US) |
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Pages | 298-302 |
Number of pages | 5 |
State | Published - 2006 |
Externally published | Yes |
Event | 3rd Conference on Foundations of Nanoscience: Self-Assembled Architectures and Devices, FNANO 2006 - Snowbird, UT, United States Duration: Apr 23 2006 → Apr 27 2006 |
Other
Other | 3rd Conference on Foundations of Nanoscience: Self-Assembled Architectures and Devices, FNANO 2006 |
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Country/Territory | United States |
City | Snowbird, UT |
Period | 4/23/06 → 4/27/06 |
ASJC Scopus subject areas
- Hardware and Architecture
- Electrical and Electronic Engineering