Traveling the vitamin B12 pathway: Oral delivery of protein and peptide drugs

Amanda K. Petrus, Timothy J. Fairchild, Robert P. Doyle

Research output: Contribution to journalShort survey

97 Scopus citations

Abstract

Oral routes of administration for therapeutic peptides and proteins face two major barriers: proteolytic degradation in the stomach and an inadequate absorption mechanism for polypeptides within the intestinal lumen. As a result, peptide-based therapeutics are administered by injection, a painful process associated with lower patient compliance. The development of a means of overcoming these two major obstacles and enabling the successful delivery of peptide therapeutics by the oral route of administration has therefore been the target of extensive scientific endeavor. This Minireview focuses on oral peptide/ protein delivery by the dietary uptake pathway for vitamin B 12. Recent progress in this field includes the delivery of erythropoietin, granulocyte-colony-stimulating factor, luteinizing-hormone- releasing hormone, and insulin.

Original languageEnglish (US)
Pages (from-to)1022-1028
Number of pages7
JournalAngewandte Chemie - International Edition
Volume48
Issue number6
DOIs
StatePublished - Jan 26 2009

Keywords

  • Bioconjugates
  • Drug delivery
  • Medicinal chemistry
  • Proteins/peptides
  • Vitamin B

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

Fingerprint Dive into the research topics of 'Traveling the vitamin B<sub>12</sub> pathway: Oral delivery of protein and peptide drugs'. Together they form a unique fingerprint.

  • Cite this