Transmembrane protein activation refined by site-specific hydration dynamics

Sunyia Hussain, John M. Franck, Songi Han

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

Proteins on film: The Overhauser dynamic nuclear polarization method resolves hydration dynamics to an unprecedented level of detail for a transmembrane protein surface. The heterogeneous hydration landscape of proteorhodopsin rearranges upon photoactivation (see picture), thus providing an insight into how water contributes to protein function even for biological systems embedded in a hydrophobic membrane.

Original languageEnglish (US)
Pages (from-to)1953-1958
Number of pages6
JournalAngewandte Chemie - International Edition
Volume52
Issue number7
DOIs
StatePublished - Feb 11 2013
Externally publishedYes

Keywords

  • EPR spectroscopy
  • dynamic nuclear polarization
  • hydration dynamics
  • membrane proteins
  • proteorhodopsin

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)

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