Towards an improved assignment of spectral features in tissue modulated non-invasive Raman spectroscopy of human fingertips

J. Chaiken, E. Voss, Rebecca J. Bussjager, George Shaheen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Scopus citations

Abstract

We have constructed a new LighTouch™ device having improved measurement and control of applied force and tissue position in noninvasive probing of human volar side fingertip capillary beds in vivo using near infrared Raman spectroscopy. These improvements have translated into improved capacity to observe and classify the behavior of specific spectral features under tissue and pulse modulation. Using this and other measurements on various other samples in vitro have demonstrated the validity of associating specific functions of the observed spectra with medically relevant quantities like hematocrit and bicarbonate ion. In addition we can say more about how much of the observed tissue modulated spectra must be associated with a "modulation defect" resulting from various errors affecting the accuracy and precision in subtraction of static tissue contributions.

Original languageEnglish (US)
Title of host publicationAdvanced Biomedical and Clinical Diagnostic Systems V
DOIs
StatePublished - Apr 30 2007
EventAdvanced Biomedical and Clinical Diagnostic Systems V - San Jose, CA, United States
Duration: Jan 21 2007Jan 27 2007

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume6430
ISSN (Print)1605-7422

Other

OtherAdvanced Biomedical and Clinical Diagnostic Systems V
CountryUnited States
CitySan Jose, CA
Period1/21/071/27/07

Keywords

  • Bicarbonate
  • Blood analysis
  • Lactate
  • Microcirculation
  • Noninvasive
  • in vivo Raman Spectroscopy

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

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  • Cite this

    Chaiken, J., Voss, E., Bussjager, R. J., & Shaheen, G. (2007). Towards an improved assignment of spectral features in tissue modulated non-invasive Raman spectroscopy of human fingertips. In Advanced Biomedical and Clinical Diagnostic Systems V [643004] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 6430). https://doi.org/10.1117/12.708010