Towards an improved assignment of spectral features in tissue modulated non-invasive Raman spectroscopy of human fingertips

Joseph Chaiken, E. Voss, Rebecca J. Bussjager, George Shaheen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Citations (Scopus)

Abstract

We have constructed a new LighTouch™ device having improved measurement and control of applied force and tissue position in noninvasive probing of human volar side fingertip capillary beds in vivo using near infrared Raman spectroscopy. These improvements have translated into improved capacity to observe and classify the behavior of specific spectral features under tissue and pulse modulation. Using this and other measurements on various other samples in vitro have demonstrated the validity of associating specific functions of the observed spectra with medically relevant quantities like hematocrit and bicarbonate ion. In addition we can say more about how much of the observed tissue modulated spectra must be associated with a "modulation defect" resulting from various errors affecting the accuracy and precision in subtraction of static tissue contributions.

Original languageEnglish (US)
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume6430
DOIs
StatePublished - 2007
EventAdvanced Biomedical and Clinical Diagnostic Systems V - San Jose, CA, United States
Duration: Jan 21 2007Jan 27 2007

Other

OtherAdvanced Biomedical and Clinical Diagnostic Systems V
CountryUnited States
CitySan Jose, CA
Period1/21/071/27/07

Fingerprint

Raman spectroscopy
Tissue
Pulse modulation
Infrared spectroscopy
Modulation
Defects
Ions

Keywords

  • Bicarbonate
  • Blood analysis
  • in vivo Raman Spectroscopy
  • Lactate
  • Microcirculation
  • Noninvasive

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Chaiken, J., Voss, E., Bussjager, R. J., & Shaheen, G. (2007). Towards an improved assignment of spectral features in tissue modulated non-invasive Raman spectroscopy of human fingertips. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE (Vol. 6430). [643004] https://doi.org/10.1117/12.708010

Towards an improved assignment of spectral features in tissue modulated non-invasive Raman spectroscopy of human fingertips. / Chaiken, Joseph; Voss, E.; Bussjager, Rebecca J.; Shaheen, George.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 6430 2007. 643004.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Chaiken, J, Voss, E, Bussjager, RJ & Shaheen, G 2007, Towards an improved assignment of spectral features in tissue modulated non-invasive Raman spectroscopy of human fingertips. in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 6430, 643004, Advanced Biomedical and Clinical Diagnostic Systems V, San Jose, CA, United States, 1/21/07. https://doi.org/10.1117/12.708010
Chaiken J, Voss E, Bussjager RJ, Shaheen G. Towards an improved assignment of spectral features in tissue modulated non-invasive Raman spectroscopy of human fingertips. In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 6430. 2007. 643004 https://doi.org/10.1117/12.708010
Chaiken, Joseph ; Voss, E. ; Bussjager, Rebecca J. ; Shaheen, George. / Towards an improved assignment of spectral features in tissue modulated non-invasive Raman spectroscopy of human fingertips. Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 6430 2007.
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