Total synthesis of pentosidine

Adam J. Rosenberg, Daniel A. Clark

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Pentosidine, a biologically important advanced glycation endproduct, has been accessed in a rapid, high-yielding manner. The synthesis was accomplished via a six-step sequence starting with 3-amino-2-chloropyridine and features a palladium-catalyzed tandem cross-coupling/cyclization to construct the imidazo[4,5-b]pyridine core.

Original languageEnglish (US)
Pages (from-to)4678-4681
Number of pages4
JournalOrganic Letters
Volume14
Issue number17
DOIs
StatePublished - Sep 7 2012

Fingerprint

Cyclization
cross coupling
Palladium
palladium
pyridines
synthesis
pentosidine
2-chloropyridine
imidazo(4,5-b)pyridine

ASJC Scopus subject areas

  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Biochemistry

Cite this

Rosenberg, A. J., & Clark, D. A. (2012). Total synthesis of pentosidine. Organic Letters, 14(17), 4678-4681. https://doi.org/10.1021/ol3021226

Total synthesis of pentosidine. / Rosenberg, Adam J.; Clark, Daniel A.

In: Organic Letters, Vol. 14, No. 17, 07.09.2012, p. 4678-4681.

Research output: Contribution to journalArticle

Rosenberg, AJ & Clark, DA 2012, 'Total synthesis of pentosidine', Organic Letters, vol. 14, no. 17, pp. 4678-4681. https://doi.org/10.1021/ol3021226
Rosenberg AJ, Clark DA. Total synthesis of pentosidine. Organic Letters. 2012 Sep 7;14(17):4678-4681. https://doi.org/10.1021/ol3021226
Rosenberg, Adam J. ; Clark, Daniel A. / Total synthesis of pentosidine. In: Organic Letters. 2012 ; Vol. 14, No. 17. pp. 4678-4681.
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