Total synthesis of pentosidine

Adam J. Rosenberg, Daniel A. Clark

Research output: Contribution to journalArticlepeer-review

21 Scopus citations


Pentosidine, a biologically important advanced glycation endproduct, has been accessed in a rapid, high-yielding manner. The synthesis was accomplished via a six-step sequence starting with 3-amino-2-chloropyridine and features a palladium-catalyzed tandem cross-coupling/cyclization to construct the imidazo[4,5-b]pyridine core.

Original languageEnglish (US)
Pages (from-to)4678-4681
Number of pages4
JournalOrganic Letters
Issue number17
StatePublished - Sep 7 2012

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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