Total synthesis of pentosidine

Adam J. Rosenberg; Daniel A. Clark

doi:10.1021/ol3021226

Total synthesis of pentosidine

Adam J. Rosenberg, Daniel A. Clark

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Pentosidine, a biologically important advanced glycation endproduct, has been accessed in a rapid, high-yielding manner. The synthesis was accomplished via a six-step sequence starting with 3-amino-2-chloropyridine and features a palladium-catalyzed tandem cross-coupling/cyclization to construct the imidazo[4,5-b]pyridine core.

Original language	English (US)
Pages (from-to)	4678-4681
Number of pages	4
Journal	Organic Letters
Volume	14
Issue number	17
DOIs	https://doi.org/10.1021/ol3021226
State	Published - Sep 7 2012

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol3021226

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title = "Total synthesis of pentosidine",

abstract = "Pentosidine, a biologically important advanced glycation endproduct, has been accessed in a rapid, high-yielding manner. The synthesis was accomplished via a six-step sequence starting with 3-amino-2-chloropyridine and features a palladium-catalyzed tandem cross-coupling/cyclization to construct the imidazo[4,5-b]pyridine core.",

author = "Rosenberg, {Adam J.} and Clark, {Daniel A.}",

year = "2012",

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AU - Clark, Daniel A.

PY - 2012/9/7

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AB - Pentosidine, a biologically important advanced glycation endproduct, has been accessed in a rapid, high-yielding manner. The synthesis was accomplished via a six-step sequence starting with 3-amino-2-chloropyridine and features a palladium-catalyzed tandem cross-coupling/cyclization to construct the imidazo[4,5-b]pyridine core.

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JO - Organic Letters

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Total synthesis of pentosidine

Abstract

ASJC Scopus subject areas

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