Total synthesis of pentosidine

Adam J. Rosenberg, Daniel A. Clark

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Pentosidine, a biologically important advanced glycation endproduct, has been accessed in a rapid, high-yielding manner. The synthesis was accomplished via a six-step sequence starting with 3-amino-2-chloropyridine and features a palladium-catalyzed tandem cross-coupling/cyclization to construct the imidazo[4,5-b]pyridine core.

Original languageEnglish (US)
Pages (from-to)4678-4681
Number of pages4
JournalOrganic Letters
Volume14
Issue number17
DOIs
StatePublished - Sep 7 2012

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Total synthesis of pentosidine'. Together they form a unique fingerprint.

  • Cite this

    Rosenberg, A. J., & Clark, D. A. (2012). Total synthesis of pentosidine. Organic Letters, 14(17), 4678-4681. https://doi.org/10.1021/ol3021226