Abstract
CTC-96, a cobalt containing complex, was tested as a putative topical therapeutic agent for the treatment of papillomavirus-induced tumors in our cottontail rabbit papillomavirus (CRPV)-rabbit model system. Following experimental infection of domestic rabbits with CRPV, CTC-96 was applied to infection sites twice daily, 5 days a week for a total of 8 weeks. Two levels of concentrations of aqueous CTC-96 were compared to placebo control-treated animals. With increasing dose of CTC-96 we observed tumors earlier, larger, and more often across eight infected sites on each animal.
Original language | English (US) |
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Pages (from-to) | 27-35 |
Number of pages | 9 |
Journal | Antiviral Research |
Volume | 24 |
Issue number | 1 |
DOIs | |
State | Published - May 1994 |
Externally published | Yes |
Keywords
- CTC-96
- Papillomavirus
- Rabbit
- Topical application
ASJC Scopus subject areas
- Pharmacology
- Virology