Topical CTC-96 accelerates wart growth in rabbits infected with cottontail rabbit papillomavirus

Ronald S. Ostrow, Susan Coughlin, Ronald C. McGlennen, Zhanjiang Liu, Daniel Zelterman, Anthony J. Faras

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

CTC-96, a cobalt containing complex, was tested as a putative topical therapeutic agent for the treatment of papillomavirus-induced tumors in our cottontail rabbit papillomavirus (CRPV)-rabbit model system. Following experimental infection of domestic rabbits with CRPV, CTC-96 was applied to infection sites twice daily, 5 days a week for a total of 8 weeks. Two levels of concentrations of aqueous CTC-96 were compared to placebo control-treated animals. With increasing dose of CTC-96 we observed tumors earlier, larger, and more often across eight infected sites on each animal.

Original languageEnglish (US)
Pages (from-to)27-35
Number of pages9
JournalAntiviral Research
Volume24
Issue number1
DOIs
StatePublished - May 1994
Externally publishedYes

Keywords

  • CTC-96
  • Papillomavirus
  • Rabbit
  • Topical application

ASJC Scopus subject areas

  • Pharmacology
  • Virology

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