Abstract
Rats maintained on a 23 1/2 hr deprivation schedule were trained to obtain water and were given a convulsive dose of Metrazol following a single trial CER training. Animals which received the drug immediately after the conditioning were "amnesic" whether they had access to their 30 min home cage water 1 hr or 5 hr following the injection. Animals given the drug 4 hr following training were only "amnesic" if the home cage watering session followed but not if it preceded the Metrazol injection. The results suggest that the time of home cage water with respect to the "amnesic" treatment is an important variable in this type of paradigm. They also suggest that the drug produces time-dependent memory impairments.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 453-461 |
| Number of pages | 9 |
| Journal | Behavioral Biology |
| Volume | 17 |
| Issue number | 4 |
| DOIs | |
| State | Published - 1976 |
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ASJC Scopus subject areas
- Physiology
- Medicine(all)
Cite this
Time-dependent performance impairments produced by metrazol : amnesia or nonspecific drug effect? / Palfai, Tibor; Albala, Bruce.
In: Behavioral Biology, Vol. 17, No. 4, 1976, p. 453-461.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Time-dependent performance impairments produced by metrazol
T2 - amnesia or nonspecific drug effect?
AU - Palfai, Tibor
AU - Albala, Bruce
PY - 1976
Y1 - 1976
N2 - Rats maintained on a 23 1/2 hr deprivation schedule were trained to obtain water and were given a convulsive dose of Metrazol following a single trial CER training. Animals which received the drug immediately after the conditioning were "amnesic" whether they had access to their 30 min home cage water 1 hr or 5 hr following the injection. Animals given the drug 4 hr following training were only "amnesic" if the home cage watering session followed but not if it preceded the Metrazol injection. The results suggest that the time of home cage water with respect to the "amnesic" treatment is an important variable in this type of paradigm. They also suggest that the drug produces time-dependent memory impairments.
AB - Rats maintained on a 23 1/2 hr deprivation schedule were trained to obtain water and were given a convulsive dose of Metrazol following a single trial CER training. Animals which received the drug immediately after the conditioning were "amnesic" whether they had access to their 30 min home cage water 1 hr or 5 hr following the injection. Animals given the drug 4 hr following training were only "amnesic" if the home cage watering session followed but not if it preceded the Metrazol injection. The results suggest that the time of home cage water with respect to the "amnesic" treatment is an important variable in this type of paradigm. They also suggest that the drug produces time-dependent memory impairments.
UR - http://www.scopus.com/inward/record.url?scp=0017134945&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0017134945&partnerID=8YFLogxK
U2 - 10.1016/S0091-6773(76)90829-4
DO - 10.1016/S0091-6773(76)90829-4
M3 - Article
VL - 17
SP - 453
EP - 461
JO - Neurobiology of Learning and Memory
JF - Neurobiology of Learning and Memory
SN - 1074-7427
IS - 4
ER -