Rats maintained on a 23 1/2 hr deprivation schedule were trained to obtain water and were given a convulsive dose of Metrazol following a single trial CER training. Animals which received the drug immediately after the conditioning were "amnesic" whether they had access to their 30 min home cage water 1 hr or 5 hr following the injection. Animals given the drug 4 hr following training were only "amnesic" if the home cage watering session followed but not if it preceded the Metrazol injection. The results suggest that the time of home cage water with respect to the "amnesic" treatment is an important variable in this type of paradigm. They also suggest that the drug produces time-dependent memory impairments.
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