Time-dependent memory deficits produced by Pentylene-tetrazol (Metrazol)-The effect of reinforcement magnitude

T. Palfai, D. Chillag

Research output: Contribution to journalArticle

16 Scopus citations


A single 50 mg/kg (i.p.) injection of Pentylene-tetrazol (Metrazol) produced retrograde amnesia (RA) for a passive avoidance trial in the mouse. Contrary to an earlier report [20], the Metrazol effect depended on the time interval between training and injection; significant performance impairments occurred when the injection was given up to 20 min but not 60 min following training. In a second experiment, it was found that the degree to which Metrazol resulted in RA depended on the reinforcement magnitude in the learning trial.

Original languageEnglish (US)
Pages (from-to)439-442
Number of pages4
JournalPhysiology and Behavior
Issue number3
StatePublished - 1971



  • Amnesia
  • Memory
  • Metrazol
  • Passive avoidance

ASJC Scopus subject areas

  • Physiology (medical)
  • Behavioral Neuroscience

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