Time-dependent memory deficits produced by Pentylene-tetrazol (Metrazol)-The effect of reinforcement magnitude

T. Palfai; D. Chillag

doi:10.1016/0031-9384(71)90325-8

Time-dependent memory deficits produced by Pentylene-tetrazol (Metrazol)-The effect of reinforcement magnitude

T. Palfai, D. Chillag

Department of Psychology

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

A single 50 mg/kg (i.p.) injection of Pentylene-tetrazol (Metrazol) produced retrograde amnesia (RA) for a passive avoidance trial in the mouse. Contrary to an earlier report [20], the Metrazol effect depended on the time interval between training and injection; significant performance impairments occurred when the injection was given up to 20 min but not 60 min following training. In a second experiment, it was found that the degree to which Metrazol resulted in RA depended on the reinforcement magnitude in the learning trial.

Original language	English (US)
Pages (from-to)	439-442
Number of pages	4
Journal	Physiology and Behavior
Volume	7
Issue number	3
DOIs	https://doi.org/10.1016/0031-9384(71)90325-8
State	Published - Sep 1971

Keywords

Amnesia
Memory
Metrazol
Passive avoidance

ASJC Scopus subject areas

Experimental and Cognitive Psychology
Behavioral Neuroscience

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10.1016/0031-9384(71)90325-8

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AB - A single 50 mg/kg (i.p.) injection of Pentylene-tetrazol (Metrazol) produced retrograde amnesia (RA) for a passive avoidance trial in the mouse. Contrary to an earlier report [20], the Metrazol effect depended on the time interval between training and injection; significant performance impairments occurred when the injection was given up to 20 min but not 60 min following training. In a second experiment, it was found that the degree to which Metrazol resulted in RA depended on the reinforcement magnitude in the learning trial.

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Time-dependent memory deficits produced by Pentylene-tetrazol (Metrazol)-The effect of reinforcement magnitude

Abstract

Keywords

ASJC Scopus subject areas

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