Time-dependent effects of Metrazol on memory

Tibor Palfai, Perry Kurtz

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

The effects of Metrazol induced seizures on memory were studied in two experiments. In Experiment 1 it was found that Metrazol given at different intervals before a single passive avoidance training trial produced graded performance impairments 24 hr later. The degree of the resulting amnesia was shown to depend on the temporal proximity of the Metrazol seizures to the training trial. In Experiment 2 Metrazol was given immediately following the passive avoidance trial but amnesia was found to develop only after several hr following the Metrazol treatment. The data are similar to those obtained with ECS.

Original languageEnglish (US)
Pages (from-to)55-59
Number of pages5
JournalPharmacology, Biochemistry and Behavior
Volume1
Issue number1
DOIs
StatePublished - Jan 1 1973

Keywords

  • Amnesia
  • Memory
  • Metrazol
  • Passive avoidance

ASJC Scopus subject areas

  • Biochemistry
  • Toxicology
  • Pharmacology
  • Clinical Biochemistry
  • Biological Psychiatry
  • Behavioral Neuroscience

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