Time-dependent effects of Metrazol on memory

Tibor Palfai; Perry Kurtz

doi:10.1016/0091-3057(73)90055-5

Time-dependent effects of Metrazol on memory

Tibor Palfai, Perry Kurtz

Department of Psychology

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

The effects of Metrazol induced seizures on memory were studied in two experiments. In Experiment 1 it was found that Metrazol given at different intervals before a single passive avoidance training trial produced graded performance impairments 24 hr later. The degree of the resulting amnesia was shown to depend on the temporal proximity of the Metrazol seizures to the training trial. In Experiment 2 Metrazol was given immediately following the passive avoidance trial but amnesia was found to develop only after several hr following the Metrazol treatment. The data are similar to those obtained with ECS.

Original language	English (US)
Pages (from-to)	55-59
Number of pages	5
Journal	Pharmacology, Biochemistry and Behavior
Volume	1
Issue number	1
DOIs	https://doi.org/10.1016/0091-3057(73)90055-5
State	Published - 1973

Keywords

Amnesia
Memory
Metrazol
Passive avoidance

ASJC Scopus subject areas

Biochemistry
Toxicology
Pharmacology
Clinical Biochemistry
Biological Psychiatry
Behavioral Neuroscience

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10.1016/0091-3057(73)90055-5

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title = "Time-dependent effects of Metrazol on memory",

abstract = "The effects of Metrazol induced seizures on memory were studied in two experiments. In Experiment 1 it was found that Metrazol given at different intervals before a single passive avoidance training trial produced graded performance impairments 24 hr later. The degree of the resulting amnesia was shown to depend on the temporal proximity of the Metrazol seizures to the training trial. In Experiment 2 Metrazol was given immediately following the passive avoidance trial but amnesia was found to develop only after several hr following the Metrazol treatment. The data are similar to those obtained with ECS.",

keywords = "Amnesia, Memory, Metrazol, Passive avoidance",

author = "Tibor Palfai and Perry Kurtz",

note = "Funding Information: This research was partially supported by an NSF Traineeship grant (GZ-2082) to the second author.",

year = "1973",

doi = "10.1016/0091-3057(73)90055-5",

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T1 - Time-dependent effects of Metrazol on memory

AU - Palfai, Tibor

AU - Kurtz, Perry

N1 - Funding Information: This research was partially supported by an NSF Traineeship grant (GZ-2082) to the second author.

PY - 1973

Y1 - 1973

N2 - The effects of Metrazol induced seizures on memory were studied in two experiments. In Experiment 1 it was found that Metrazol given at different intervals before a single passive avoidance training trial produced graded performance impairments 24 hr later. The degree of the resulting amnesia was shown to depend on the temporal proximity of the Metrazol seizures to the training trial. In Experiment 2 Metrazol was given immediately following the passive avoidance trial but amnesia was found to develop only after several hr following the Metrazol treatment. The data are similar to those obtained with ECS.

AB - The effects of Metrazol induced seizures on memory were studied in two experiments. In Experiment 1 it was found that Metrazol given at different intervals before a single passive avoidance training trial produced graded performance impairments 24 hr later. The degree of the resulting amnesia was shown to depend on the temporal proximity of the Metrazol seizures to the training trial. In Experiment 2 Metrazol was given immediately following the passive avoidance trial but amnesia was found to develop only after several hr following the Metrazol treatment. The data are similar to those obtained with ECS.

KW - Amnesia

KW - Memory

KW - Metrazol

KW - Passive avoidance

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JO - Pharmacology, Biochemistry and Behavior

JF - Pharmacology, Biochemistry and Behavior

IS - 1

ER -

Time-dependent effects of Metrazol on memory

Abstract

Keywords

ASJC Scopus subject areas

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