TY - JOUR
T1 - Thermogenic adipose tissues
T2 - Promising therapeutic targets for metabolic diseases
AU - Pahlavani, Mandana
AU - Pham, Kenneth
AU - Kalupahana, Nishan Sudheera
AU - Morovati, Ashti
AU - Ramalingam, Latha
AU - Abidi, Hussain
AU - Kiridana, Vasana
AU - Moustaid-Moussa, Naima
N1 - Publisher Copyright:
© 2024 Elsevier Inc.
PY - 2025/3
Y1 - 2025/3
N2 - The ongoing increase in the prevalence of obesity and its comorbidities such as cardiovascular disease, type 2 diabetes (T2D) and dyslipidemia warrants discovery of novel therapeutic options for these metabolic diseases. Obesity is characterized by white adipose tissue expansion due to chronic positive energy balance as a result of excessive energy intake and/or reduced energy expenditure. Despite various efforts to prevent or reduce obesity including lifestyle and behavioral interventions, surgical weight reduction approaches and pharmacological methods, there has been limited success in significantly reducing obesity prevalence. Recent research has shown that thermogenic adipocyte (brown and beige) activation or formation, respectively, could potentially act as a therapeutic strategy to ameliorate obesity and its related disorders. This can be achieved through the ability of these thermogenic cells to enhance energy expenditure and regulate circulating levels of glucose and lipids. Thus, unraveling the molecular mechanisms behind the formation and activation of brown and beige adipocytes holds the potential for probable therapeutic paths to combat obesity. In this review, we provide a comprehensive update on the development and regulation of different adipose tissue types. We also emphasize recent interventions in harnessing therapeutic potential of thermogenic adipocytes by bioactive compounds and new pharmacological anti-obesity agents.
AB - The ongoing increase in the prevalence of obesity and its comorbidities such as cardiovascular disease, type 2 diabetes (T2D) and dyslipidemia warrants discovery of novel therapeutic options for these metabolic diseases. Obesity is characterized by white adipose tissue expansion due to chronic positive energy balance as a result of excessive energy intake and/or reduced energy expenditure. Despite various efforts to prevent or reduce obesity including lifestyle and behavioral interventions, surgical weight reduction approaches and pharmacological methods, there has been limited success in significantly reducing obesity prevalence. Recent research has shown that thermogenic adipocyte (brown and beige) activation or formation, respectively, could potentially act as a therapeutic strategy to ameliorate obesity and its related disorders. This can be achieved through the ability of these thermogenic cells to enhance energy expenditure and regulate circulating levels of glucose and lipids. Thus, unraveling the molecular mechanisms behind the formation and activation of brown and beige adipocytes holds the potential for probable therapeutic paths to combat obesity. In this review, we provide a comprehensive update on the development and regulation of different adipose tissue types. We also emphasize recent interventions in harnessing therapeutic potential of thermogenic adipocytes by bioactive compounds and new pharmacological anti-obesity agents.
KW - Beige adipose tissue
KW - Bioactive compounds
KW - Brown adipose tissue
KW - GLP1-RA
KW - Lipid metabolites
KW - MicroRNA
KW - Obesity
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U2 - 10.1016/j.jnutbio.2024.109832
DO - 10.1016/j.jnutbio.2024.109832
M3 - Review article
C2 - 39653156
AN - SCOPUS:85213573131
SN - 0955-2863
VL - 137
JO - Journal of Nutritional Biochemistry
JF - Journal of Nutritional Biochemistry
M1 - 109832
ER -