Thermally and Photothermally Triggered Cytocompatible Triple-Shape-Memory Polymer Based on a Graphene Oxide-Containing Poly(ϵ-caprolactone) and Acrylate Composite

Junjiang Chen, Shiyang Sun, Mark M. Macios, Elizabeth Oguntade, Ameya R. Narkar, Patrick T. Mather, James H. Henderson

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Triple-shape-memory polymers (triple-SMPs) are a class of polymers capable of fixing two temporary shapes and recovering sequentially from the first temporary shape to the second temporary shape and, last, to the permanent shape. To accomplish a sequential shape change, a triple-SMP must have two separate shape-fixing mechanisms triggerable by distinct stimuli. Despite the biomedical potential of triple-SMPs, a triple-SMP that with cells present can undergo two different shape changes via two distinct cytocompatible triggers has not previously been demonstrated. Here, we report the design and characterization of a cytocompatible triple-SMP material that responds separately to thermal and light triggers to undergo two distinct shape changes under cytocompatible conditions. Tandem triggering was achieved via a photothermally triggered component, comprising poly(ϵ-caprolactone) (PCL) fibers with graphene oxide (GO) particles physically attached, embedded in a thermally triggered component, comprising a tert-butyl acrylate-butyl acrylate (tBA-BA) matrix. The material was characterized in terms of thermal properties, surface morphology, shape-memory performance, and cytocompatibility during shape change. Collectively, the results demonstrate cytocompatible triple-shape behavior with a relatively larger thermal shape change (an average of 20.4 ± 4.2% strain recovered for all PCL-containing groups) followed by a smaller photothermal shape change (an average of 3.5 ± 0.8% strain recovered for all PCL-GO-containing groups; samples without GO showed no recovery) with greater than 95% cell viability on the triple-SMP materials, establishing the feasibility of triple-shape memory to be incorporated into biomedical devices and strategies.

Original languageEnglish (US)
Pages (from-to)50962-50972
Number of pages11
JournalACS Applied Materials and Interfaces
Volume15
Issue number44
DOIs
StatePublished - Nov 8 2023

Keywords

  • cytocompatible
  • functional materials
  • light responsive
  • smart materials
  • thermal responsive
  • triple-shape-memory polymers

ASJC Scopus subject areas

  • General Materials Science

Fingerprint

Dive into the research topics of 'Thermally and Photothermally Triggered Cytocompatible Triple-Shape-Memory Polymer Based on a Graphene Oxide-Containing Poly(ϵ-caprolactone) and Acrylate Composite'. Together they form a unique fingerprint.

Cite this