The vimentin cytoskeleton: when polymer physics meets cell biology

Alison E. Patteson, Robert J. Carroll, Daniel V. Iwamoto, Paul A. Janmey

Research output: Contribution to journalReview articlepeer-review

Abstract

The proper functions of tissues depend on the ability of cells to withstand stress and maintain shape. Central to this process is the cytoskeleton, comprised of three polymeric networks: F-actin, microtubules, and intermediate filaments (IFs). IF proteins are among the most abundant cytoskeletal proteins in cells; yet they remain some of the least understood. Their structure and function deviate from those of their cytoskeletal partners, F-actin and microtubules. IF networks show a unique combination of extensibility, flexibility and toughness that confers mechanical resilience to the cell. Vimentin is an IF protein expressed in mesenchymal cells. This review highlights exciting new results on the physical biology of vimentin intermediate filaments and their role in allowing whole cells and tissues to cope with stress.

Original languageEnglish (US)
Article number011001
JournalPhysical Biology
Volume18
Issue number1
DOIs
StatePublished - Jan 2021

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Molecular Biology
  • Cell Biology

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