The serpin superfamily in channel catfish: Identification, phylogenetic analysis and expression profiling in mucosal tissues after bacterial infections

Yun Li, Shikai Liu, Zhenkui Qin, Jun Yao, Chen Jiang, Lin Song, Rex Dunham, Zhanjiang Liu

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

The superfamily of serine protease inhibitors (serpins) are broadly distributed in all kingdoms of life. Serpins play critical roles in an array of fundamental biological processes. In this study, we identified a complete set of 25 serpin genes from channel catfish genome by comprehensive data mining of existing genomic resources. Phylogenetic analysis verified their identities and supported the classification of serpins into six families as in mammals. Extensive comparative genomic analyses suggested that most serpins were conserved among vertebrates, while some were lineage-specific. Analysis of serpin gene expression in mucosal tissues after bacterial infections indicated that serpin genes were regulated in a tissue-specific and time-dependent manner. Distinct expression patterns between infections of the two pathogens were observed, indicating that much more rapid host responses of serpin expression were initiated after ESC infection than after columnaris infection. These studies set the foundation for future studies of host-pathogen interactions.

Original languageEnglish (US)
Pages (from-to)267-277
Number of pages11
JournalDevelopmental and Comparative Immunology
Volume49
Issue number2
DOIs
StatePublished - Apr 1 2015
Externally publishedYes

Keywords

  • Catfish
  • Expression
  • Genome
  • Infection
  • Mucosal immunity
  • Serpin

ASJC Scopus subject areas

  • Immunology
  • Developmental Biology

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