The role of peripheral catecholamines in reserpine-induced amnesia

Tibor Palfai, Thomas J. Walsh

Research output: Contribution to journalArticlepeer-review

16 Scopus citations

Abstract

The effect of peripherally administered catecholamines on reserpine-induced amnesia of a PA training in mice was investigated. The amnesic effect of reserpine could be blocked with 50 mg/kg DA or 0.1 or 0.75 mg/kg NE when given ip either before, immediately, or 10 min after but not 90 min following PA. Epinephrine or a lower dose of DA could not attentrate the reserpine-induced amnesia. Syrosingopine, the peripherally acting reserpine analogue also produced time-dependent retention impairments. The amnesic effects of these Rauwolfia alkaloids were interpreted in terms of their peripheral antiadrenergic actions.

Original languageEnglish (US)
Pages (from-to)423-432
Number of pages10
JournalBehavioral and Neural Biology
Volume27
Issue number4
DOIs
StatePublished - Dec 1979

ASJC Scopus subject areas

  • Physiology

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