The role of peripheral catecholamines in reserpine-induced amnesia

Tibor Palfai; Thomas J. Walsh

doi:10.1016/S0163-1047(79)91998-8

The role of peripheral catecholamines in reserpine-induced amnesia

Tibor Palfai, Thomas J. Walsh

Department of Psychology

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

The effect of peripherally administered catecholamines on reserpine-induced amnesia of a PA training in mice was investigated. The amnesic effect of reserpine could be blocked with 50 mg/kg DA or 0.1 or 0.75 mg/kg NE when given ip either before, immediately, or 10 min after but not 90 min following PA. Epinephrine or a lower dose of DA could not attentrate the reserpine-induced amnesia. Syrosingopine, the peripherally acting reserpine analogue also produced time-dependent retention impairments. The amnesic effects of these Rauwolfia alkaloids were interpreted in terms of their peripheral antiadrenergic actions.

Original language	English (US)
Pages (from-to)	423-432
Number of pages	10
Journal	Behavioral and Neural Biology
Volume	27
Issue number	4
DOIs	https://doi.org/10.1016/S0163-1047(79)91998-8
State	Published - Dec 1979

ASJC Scopus subject areas

Physiology

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10.1016/S0163-1047(79)91998-8

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title = "The role of peripheral catecholamines in reserpine-induced amnesia",

abstract = "The effect of peripherally administered catecholamines on reserpine-induced amnesia of a PA training in mice was investigated. The amnesic effect of reserpine could be blocked with 50 mg/kg DA or 0.1 or 0.75 mg/kg NE when given ip either before, immediately, or 10 min after but not 90 min following PA. Epinephrine or a lower dose of DA could not attentrate the reserpine-induced amnesia. Syrosingopine, the peripherally acting reserpine analogue also produced time-dependent retention impairments. The amnesic effects of these Rauwolfia alkaloids were interpreted in terms of their peripheral antiadrenergic actions.",

author = "Tibor Palfai and Walsh, {Thomas J.}",

note = "Funding Information: Supported by Syracuse University Institutional Grant. We would like to thank Ciba-Geigy for the generous gift of the syrosingopine. Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",

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AU - Walsh, Thomas J.

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N2 - The effect of peripherally administered catecholamines on reserpine-induced amnesia of a PA training in mice was investigated. The amnesic effect of reserpine could be blocked with 50 mg/kg DA or 0.1 or 0.75 mg/kg NE when given ip either before, immediately, or 10 min after but not 90 min following PA. Epinephrine or a lower dose of DA could not attentrate the reserpine-induced amnesia. Syrosingopine, the peripherally acting reserpine analogue also produced time-dependent retention impairments. The amnesic effects of these Rauwolfia alkaloids were interpreted in terms of their peripheral antiadrenergic actions.

AB - The effect of peripherally administered catecholamines on reserpine-induced amnesia of a PA training in mice was investigated. The amnesic effect of reserpine could be blocked with 50 mg/kg DA or 0.1 or 0.75 mg/kg NE when given ip either before, immediately, or 10 min after but not 90 min following PA. Epinephrine or a lower dose of DA could not attentrate the reserpine-induced amnesia. Syrosingopine, the peripherally acting reserpine analogue also produced time-dependent retention impairments. The amnesic effects of these Rauwolfia alkaloids were interpreted in terms of their peripheral antiadrenergic actions.

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The role of peripheral catecholamines in reserpine-induced amnesia

Abstract

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