The pressure-dependency of localmeasures of Arterial stiffness

Gabriel H. Zieff, Kevin Heffernan, Keeron Stone, Simon Fryer, Daniel Credeur, Erik D. Hanson, James Faulkner, Lee Stoner

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


Objective: To determine which ultrasound-based, singlepoint arterial stiffness estimate is least dependent on blood pressure (BP) to improve assessment of local vascular function. Methods: Ultrasound was used to assess blood flow and diameters at the left brachial artery of 20 healthy adults [55% female, 27.9 years (5.2), 24.2 (2.8) kg/m2]. BP of both arms was measured simultaneously. Experimental (left) arm BP was then systematically manipulated by adjusting its position ABOVE (+30°) and BELOW (-30°) heart level in a randomized order following measurement at heart level (0°). The control (right) arm remained at heart level. Six stiffness measurements were calculated: Compliance, distensibility, beta-stiffness, and three estimates of pulse wave velocity (PWV) (Bramwell Hill, blood flow, and beta-stiffness). We considered the measurement technique with the least significant change across positions to be the least pressure-dependent. Results: There was a large effect change in mean arterial pressure (n2p=0.75, P<0.001) in the experimental arm when it was ABOVE (Δ-4.4mmHg) and BELOW (Δ10.4mmHg) heart level. There was a main effect (P<0.05) of arm position on all arterial stiffness measures. From least to most pressure-dependent, the arterial stiffness measurements were: PWV (blood flow method), compliance coefficient, beta-stiffness, distensibility coefficient, PWV (Bramwell-Hill method), and PWV (beta-stiffness index method). Conclusion: All single-point measures assessed are pressure-dependent. The PWV (blood flow method) may be the least pressure-dependent single-point measure, and may be the most suitable single-point measure to assess local vascular function.

Original languageEnglish (US)
Pages (from-to)956-963
Number of pages8
JournalJournal of hypertension
Issue number5
StatePublished - May 2019


  • Atherosclerosis
  • Blood pressure
  • Hydrostatic pressure
  • Posture
  • Vascular stiffness

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine


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