The pK_a Values of Acidic and Basic Residues Buried at the Same Internal Location in a Protein Are Governed by Different Factors

Keyphrases

• Amino Group 33%
• Backbone Amide 33%
• Basic Residues 100%
• Carboxyl 33%
• Complex Interplay 33%
• Computational Methods 33%
• Conformational Reorganization 33%
• Coulomb Interaction 66%
• Dehydration 33%
• Interactions with Surfaces 33%
• Internal Group 100%
• Ion Pairs 33%
• Ionizable Groups 66%
• Local Polarity 33%
• Molecular Determinants 33%
• Oxygen Atom 33%
• Polar Interactions 33%
• Side Chain 66%
• Staphylococcal nuclease 33%
• Structural Reorganization 100%
• Structural Water 33%
• Water Penetration 33%

Biochemistry, Genetics and Molecular Biology

• Micrococcal Nuclease 100%