The octanoylated energy regulating hormone ghrelin: An expanded view of ghrelin’s biological interactions and avenues for controlling ghrelin signaling

Elizabeth R. Cleverdon, Kayleigh R. McGovern-Gooch, James L Hougland

Research output: Contribution to journalReview article

4 Scopus citations

Abstract

Ghrelin is a small peptide hormone that requires a unique post-translational modification, serine octanoylation, to bind and activate the GHS-R1a receptor. Initially demonstrated to stimulate hunger and appetite, ghrelin-dependent signaling is implicated in a variety of neurological and physiological processes influencing diseases such as diabetes, obesity, and Prader-Willi syndrome. In addition to its cognate receptor, recent studies have revealed ghrelin interacts with a range of binding partners within the bloodstream. Defining the scope of ghrelin’s interactions within the body, understanding how these interactions work in concert to modulate ghrelin signaling, and developing molecular tools for controlling ghrelin signaling are essential for exploiting ghrelin for therapeutic effect. In this review, we discuss recent findings regarding the biological effects of ghrelin signaling, outline binding partners that control ghrelin trafficking and stability in circulation, and summarize the current landscape of inhibitors targeting ghrelin octanoylation.

Original languageEnglish (US)
Pages (from-to)111-124
Number of pages14
JournalMolecular Membrane Biology
Volume33
Issue number6-8
DOIs
StatePublished - Nov 16 2016

Keywords

  • Ghrelin
  • ghrelin O-acyltransferase
  • ghrelin O-acyltransferase inhibitors
  • protein acylation

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

Fingerprint Dive into the research topics of 'The octanoylated energy regulating hormone ghrelin: An expanded view of ghrelin’s biological interactions and avenues for controlling ghrelin signaling'. Together they form a unique fingerprint.

  • Cite this