The Nla6S protein of Myxococcus xanthus is the prototype for a new family of bacterial histidine kinases

Zaara Sarwar, Anthony G. Garza

Research output: Contribution to journalArticle

4 Scopus citations


Myxococcus xanthus has a large number of histidine kinase (HK) signal transduction proteins and many of these HKs are important for fruiting body development. Nla6S is an uncharacterized HK that lacks many of the conserved sequence motifs of typical HK proteins. In this study, we report that expression of the nla6S gene increases about sixfold during fruiting body development, that the Nla6S protein has the in vitro properties of HKs and that Nla6S is the prototype for a new family of HKs. To date, these Nla6-like HKs are found only in fruiting members of the Cystobacterineae suborder of the myxobacteria.

Original languageEnglish (US)
Pages (from-to)86-94
Number of pages9
JournalFEMS Microbiology Letters
Issue number2
StatePublished - Oct 1 2012



  • Cystobacterineae
  • Histidine kinase
  • Myxococcus xanthus fruiting body development
  • Two-component systems

ASJC Scopus subject areas

  • Microbiology
  • Molecular Biology
  • Genetics

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