The Influence of Transcranial Magnetic Stimulation Interpulse Interval Duration on Knee Extensor Corticospinal Excitability

Kevan S. Knowles, Jonathan P. Beausejour, Kylie K. Harmon, Ryan M. Girts, David H. Fukuda, Dawson J. Kidgell, Matt S. Stock

Research output: Contribution to journalArticlepeer-review

Abstract

Background/Purpose: To examine the influence of interpulse interval duration on knee extensor corticospinal excitability. Methods: Seventeen college-aged males and females participated in a single laboratory visit, during which 25 single transcranial magnetic stimulation pulses were delivered to the motor cortex with interpulse intervals of 5, 10, 15, and 20 sec. Surface electromyographic signals were detected from the dominant vastus lateralis and rectus femoris. Motor evoked potential amplitude was compared across the four conditions. Results: For the vastus lateralis, the Friedman test indicated significant differences among conditions (chi-squared [3] = 7.80, p = 0.050); however, there were no pairwise differences (p ‡ 0.094) and small effect sizes (d £ 0.269). For the rectus femoris, the Friedman test results showed no significant differences among conditions (chi-squared [3] = 2.44, p = 0.487). Across all muscles and conditions, low intraclass correlation coefficients and high standard errors of measurement were suggestive of poor reliability. Conclusion: Unlike resting hand muscles, interpulse interval duration has little influence on corticospinal excitability for the knee extensors during active contractions.

Original languageEnglish (US)
Pages (from-to)521-527
Number of pages7
JournalBrain Connectivity
Volume13
Issue number9
DOIs
StatePublished - Nov 1 2023

Keywords

  • AMT
  • EMG
  • MEP amplitude
  • TMS
  • corticospinal excitability
  • interpulse interval duration

ASJC Scopus subject areas

  • General Neuroscience

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