The effect of reserpine, syrosingopine, and guanethidine on the retention of discriminated escape reversal: Peripherally administered catecholamines cannot reverse the reserpine amnesia in this situation

Tibor Palfai, Lawrence Wichlinski, Oliver M. Brown

Research output: Contribution to journalArticle

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Abstract

In a series of experiments, the effects of reserpine, syrosingopine, and guanethidine on retention of a discriminated escape reversal training were investigated in mice. The peripherally and centrally acting reserpine produced amnesia while the primarily peripherally acting compounds, syrosingopine or guanethidine, did not produce amnesia even when given in high dosages or when training was given with low footshock. Unlike in the passive avoidance situation, peripherally administered norepinephrine or dopamine was not able to attenuate the reserpine-induced amnesia. The results were discussed in terms of the role of biogenic amines in memory formation.

Original languageEnglish (US)
Pages (from-to)120-126
Number of pages7
JournalBehavioral and Neural Biology
Volume38
Issue number1
DOIs
StatePublished - 1983

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ASJC Scopus subject areas

  • Physiology

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