The correlation between 13C chemical shifts of DNA and interstrand purine-purine clash

You jie Zhang, Ke yu Wang, P. N. Borer, G. C. Levy

Research output: Contribution to journalArticle

1 Scopus citations

Abstract

The correlation between 13C chemical shifts of DNA and structure parameters (the main axis helix twist angle Ω, base-plane roll angle ρ{variant}, main chain torsion angle δ and propeller twist angle ω) has been discovered and proved indirectly. The carbons relating to the structure parameters have been found and interpreted theoretically. Relative variations in chemical shifts of these carbons obviously reflect purine-purine clash (steric hindrance) and have been compared with sum functions Σ of Calladine-Dickerson rules. It would be possible to provide the information about conformation of DNA from 13C NMR spectra and to observe the structure parameters of Ω, ρ{variant}, δ and ω of DNA in solution.

Original languageEnglish (US)
Pages (from-to)1416-1424
Number of pages9
JournalScience in China (Scientia Sinica) Series B
Volume35
Issue number12
StatePublished - Dec 1 1992

Keywords

  • C NMR
  • Calladine-Dickerson rules
  • DNA
  • purine-purine clash

ASJC Scopus subject areas

  • Environmental Science(all)
  • Engineering(all)
  • Earth and Planetary Sciences(all)

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    Zhang, Y. J., Wang, K. Y., Borer, P. N., & Levy, G. C. (1992). The correlation between 13C chemical shifts of DNA and interstrand purine-purine clash. Science in China (Scientia Sinica) Series B, 35(12), 1416-1424.