The coordination chemistry of bleomycin: a review

James C. Dabrowiak

Research output: Contribution to journalArticle

58 Scopus citations

Abstract

It is evident that bleomycin is a "something for everyone antibiotic." The mechanism, which involves an important anticancer drug, a metal ion, and DNA, attracts a broad spectrum of scientific intellects and publications on the antibiotic can be found in a variety of different journals. For the inorganic chemist the challenges with bleomycin are just beginning. While the large size of the molecule complicates the study of metal binding phenomena, the drug is small enough to be studied using the structural techniques normally employed by the coordination chemist, e.g., 1H and 13C nmr. Although significant progress toward understanding the structure and chemistry of the important metallobleomycins has been made, much remains yet to be done. It is hoped that by placing in perspective the accomplishments of the past, this review will help to more clearly define the course of future experimentation on the antibiotic.

Original languageEnglish (US)
Pages (from-to)317-337
Number of pages21
JournalJournal of Inorganic Biochemistry
Volume13
Issue number4
DOIs
StatePublished - 1980

ASJC Scopus subject areas

  • Biochemistry
  • Inorganic Chemistry

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