The coordination chemistry of bio-relevant ligands and their magnesium complexes

Derek R. Cas; Jon Zubieta; Robert P. Doyl

doi:10.3390/molecules25143172

The coordination chemistry of bio-relevant ligands and their magnesium complexes

Derek R. Cas, Jon Zubieta, Robert P. Doyl

Department of Chemistry

Research output: Contribution to journal › Review article › peer-review

19 Scopus citations

Abstract

The coordination chemistry of magnesium (Mg2+) was extensively explored. More recently; magnesium; which plays a role in over 80% of metabolic functions and governs over 350 enzymatic processes; is becoming increasingly linked to chronic disease-predominantly due to magnesium deficiency (hypomagnesemia). Supplemental dietary magnesium utilizing biorelevant chelate ligands is a proven method for counteracting hypomagnesemia. However, the coordination chemistry of such bio-relevant magnesium complexes is yet to be extensively explored or elucidated. It is the aim of this review to comprehensively describe what is currently known about common bio-relevant magnesium complexes from the perspective of coordination chemistry.

Original language	English (US)
Article number	3172
Journal	Molecules
Volume	25
Issue number	14
DOIs	https://doi.org/10.3390/molecules25143172
State	Published - Jul 2020

Keywords

Chelates
Coordination chemistry
Hypomagnesemia
Magnesium
Nutraceuticals

ASJC Scopus subject areas

Analytical Chemistry
Chemistry (miscellaneous)
Molecular Medicine
Pharmaceutical Science
Drug Discovery
Physical and Theoretical Chemistry
Organic Chemistry

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10.3390/molecules25143172

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title = "The coordination chemistry of bio-relevant ligands and their magnesium complexes",

abstract = "The coordination chemistry of magnesium (Mg2+) was extensively explored. More recently; magnesium; which plays a role in over 80% of metabolic functions and governs over 350 enzymatic processes; is becoming increasingly linked to chronic disease-predominantly due to magnesium deficiency (hypomagnesemia). Supplemental dietary magnesium utilizing biorelevant chelate ligands is a proven method for counteracting hypomagnesemia. However, the coordination chemistry of such bio-relevant magnesium complexes is yet to be extensively explored or elucidated. It is the aim of this review to comprehensively describe what is currently known about common bio-relevant magnesium complexes from the perspective of coordination chemistry.",

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AU - Zubieta, Jon

AU - Doyl, Robert P.

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N2 - The coordination chemistry of magnesium (Mg2+) was extensively explored. More recently; magnesium; which plays a role in over 80% of metabolic functions and governs over 350 enzymatic processes; is becoming increasingly linked to chronic disease-predominantly due to magnesium deficiency (hypomagnesemia). Supplemental dietary magnesium utilizing biorelevant chelate ligands is a proven method for counteracting hypomagnesemia. However, the coordination chemistry of such bio-relevant magnesium complexes is yet to be extensively explored or elucidated. It is the aim of this review to comprehensively describe what is currently known about common bio-relevant magnesium complexes from the perspective of coordination chemistry.

AB - The coordination chemistry of magnesium (Mg2+) was extensively explored. More recently; magnesium; which plays a role in over 80% of metabolic functions and governs over 350 enzymatic processes; is becoming increasingly linked to chronic disease-predominantly due to magnesium deficiency (hypomagnesemia). Supplemental dietary magnesium utilizing biorelevant chelate ligands is a proven method for counteracting hypomagnesemia. However, the coordination chemistry of such bio-relevant magnesium complexes is yet to be extensively explored or elucidated. It is the aim of this review to comprehensively describe what is currently known about common bio-relevant magnesium complexes from the perspective of coordination chemistry.

KW - Chelates

KW - Coordination chemistry

KW - Hypomagnesemia

KW - Magnesium

KW - Nutraceuticals

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The coordination chemistry of bio-relevant ligands and their magnesium complexes

Abstract

Keywords

ASJC Scopus subject areas

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