The coordination chemistry of bio-relevant ligands and their magnesium complexes

Derek R. Cas, Jon Zubieta, Robert P. Doyl

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations


The coordination chemistry of magnesium (Mg2+) was extensively explored. More recently; magnesium; which plays a role in over 80% of metabolic functions and governs over 350 enzymatic processes; is becoming increasingly linked to chronic disease-predominantly due to magnesium deficiency (hypomagnesemia). Supplemental dietary magnesium utilizing biorelevant chelate ligands is a proven method for counteracting hypomagnesemia. However, the coordination chemistry of such bio-relevant magnesium complexes is yet to be extensively explored or elucidated. It is the aim of this review to comprehensively describe what is currently known about common bio-relevant magnesium complexes from the perspective of coordination chemistry.

Original languageEnglish (US)
Article number3172
Issue number14
StatePublished - Jul 2020


  • Chelates
  • Coordination chemistry
  • Hypomagnesemia
  • Magnesium
  • Nutraceuticals

ASJC Scopus subject areas

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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