TY - JOUR
T1 - The coordination chemistry of 1,4,7,10-tetraazacyclododecane-N,N′,N″,N′″-tetra acetic acid (H4DOTA)
T2 - Structural overview and analyses on structure-stability relationships
AU - Viola-Villegas, Nerissa
AU - Doyle, Robert P.
PY - 2009/7
Y1 - 2009/7
N2 - 1,4,7,10-Tetraazacyclododecane-N,N′,N″,N′″-tetra acetic acid (DOTA) is one of the preeminent carriers of metal-based radiopharmaceutics and imaging contrast agents. This review focuses on the coordination chemistry of metal-DOTA complexes with a view to addressing the variability of structures obtained and gaining insight into its diversity. Correlations on thermodynamic stabilities with structural motifs are reported. Observed trends are analyzed with a view to providing a structure-stability relationship.
AB - 1,4,7,10-Tetraazacyclododecane-N,N′,N″,N′″-tetra acetic acid (DOTA) is one of the preeminent carriers of metal-based radiopharmaceutics and imaging contrast agents. This review focuses on the coordination chemistry of metal-DOTA complexes with a view to addressing the variability of structures obtained and gaining insight into its diversity. Correlations on thermodynamic stabilities with structural motifs are reported. Observed trends are analyzed with a view to providing a structure-stability relationship.
KW - DOTA
KW - Lanthanides
KW - Structure-stability
KW - Transition metals
KW - X-ray crystal structures
UR - http://www.scopus.com/inward/record.url?scp=65549152224&partnerID=8YFLogxK
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U2 - 10.1016/j.ccr.2009.03.013
DO - 10.1016/j.ccr.2009.03.013
M3 - Review article
AN - SCOPUS:65549152224
SN - 0010-8545
VL - 253
SP - 1906
EP - 1925
JO - Coordination Chemistry Reviews
JF - Coordination Chemistry Reviews
IS - 13-14
ER -