The coordination chemistry of 1,4,7,10-tetraazacyclododecane-N,N′,N″,N′″-tetra acetic acid (H4DOTA): Structural overview and analyses on structure-stability relationships

Nerissa Viola-Villegas, Robert P. Doyle

Research output: Contribution to journalReview article

98 Scopus citations

Abstract

1,4,7,10-Tetraazacyclododecane-N,N′,N″,N′″-tetra acetic acid (DOTA) is one of the preeminent carriers of metal-based radiopharmaceutics and imaging contrast agents. This review focuses on the coordination chemistry of metal-DOTA complexes with a view to addressing the variability of structures obtained and gaining insight into its diversity. Correlations on thermodynamic stabilities with structural motifs are reported. Observed trends are analyzed with a view to providing a structure-stability relationship.

Original languageEnglish (US)
Pages (from-to)1906-1925
Number of pages20
JournalCoordination Chemistry Reviews
Volume253
Issue number13-14
DOIs
StatePublished - Jul 1 2009

Keywords

  • DOTA
  • Lanthanides
  • Structure-stability
  • Transition metals
  • X-ray crystal structures

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Inorganic Chemistry
  • Materials Chemistry

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