The control of sexual development in Drosophila melanogaster: genetic and molecular analysis of a genetic regulatory hierarchy - a minireview

John M. Belote

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

Genetic analyses of mutants affecting the sexual development of the fruitfly, Drosophila melanogaster, have led to a genetic model that describes how the wild-type genes interact with one another as parts of a single regulatory pathway. More recent molecular studies on some of these sex differentiation regulatory genes have lent support to this genetic model, and have defined the molecular nature of some of these genetic interactions. One surprising feature of the regulatory hierarchy to emerge from these molecular studies is that many of the sex-specific genetic switches in this pathway are not transcriptional regulation events but, rather, are based on sex-specific alternative RNA processing events (pre-mRNA splicing and/or polyadenylation site selection).

Original languageEnglish (US)
Pages (from-to)161-167
Number of pages7
JournalGene
Volume82
Issue number1
DOIs
StatePublished - Oct 15 1989

Keywords

  • FEMALE/MALE switch
  • ON/OFF regulation
  • Sex determination
  • alternative RNA splicing
  • developmental genetics
  • regulatory cascades

ASJC Scopus subject areas

  • Genetics

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