@article{15845d0712a040c4ae02b1aee3683e86,
title = "The control of alternative splicing at genes regulating sexual differentiation in D. melanogaster",
abstract = "The transformer (tra) and doublesex (dsx) genes produce sex-specific transcripts that are generated by differential RNA processing. We have examined the effects of mutants in other regulatory genes controlling sexual differentiation on the patterns of processing of the tra and dsx RNA transcripts. Our results demonstrate that the genes suggested by genetic studies to act upstream of tra or dsx in the sex determination hierarchy regulate these two loci at the level of RNA processing. Our data suggest that the order of interaction of the factors controlling sex is X:A>Sxl>tra≥tra-2>dsx≥ix>terminal differentiation. While these results cannot preclude regulatory interactions at other levels, the regulation of RNA splicing revealed by these experiments is sufficient to account for all of the known functional interactions between the regulatory genes in this hierarchy.",
author = "Nagoshi, {Rodney N.} and Michael McKeown and Burtis, {Kenneth C.} and Belote, {John M.} and Baker, {Bruce S.}",
note = "Funding Information: We :hank I borras W Clone tos~~p~lylng Sx: stccks. Barhara Taylor for orle of Ihe k-2 stocks used. and Thoma; Go*alskl ar;d &rap, Smol k-Utlaul lo1 helpful comments on ttme manuscript Tt,ls ,tiork wds sup-po,ted by grants from the NatlanaI lnstltutes of Health to A N N M M J M 6 and B 6 K B was supported ~){\textquoteleft}a grant from the Helen Hay Whitney Fourdarlon M M is a Pew fellow lr Rlcmedlcal Sciences Parts of tms Work were supported hy f,lnds from {\textquoteleft}he Rice and Mellon Fourdatlons to the Salk lnslitute The costs of publlcatlon of this article were def,ayec n t;a{\textquoteright}l by the payment of page charges TIIS ar!lcle ~mub: ttlerefore be pereby marked advertisemcni“ in accordance wlti 18 USC Se&on 173C solely lnclcate th fact Copyright: Copyright 2014 Elsevier B.V., All rights reserved.",
year = "1988",
month = apr,
day = "22",
doi = "10.1016/0092-8674(88)90384-4",
language = "English (US)",
volume = "53",
pages = "229--236",
journal = "Cell",
issn = "0092-8674",
publisher = "Cell Press",
number = "2",
}