The centrosome, a multitalented renaissance organelle

Anastassiia Vertii, Heidi Hehnly, Stephen Doxsey

Research output: Contribution to journalArticlepeer-review

74 Scopus citations


The centrosome acts as a microtubule-organizing center (MTOC) from the G1to G2phases of the cell cycle; it can mature into a spindle pole during mitosis and/or transition into a ciliumby elongating microtubules (MTs) from the basal body on cell differentiation or cell cycle arrest. New studies hint that the centrosome functions in more than MTorganization. For instance, it has recently been shown that a specific substructure of the centrosome—the mother centriole appendages—are required for the recycling of endosomes back to the plasma membrane. This alone could have important implications for a renaissance in our understanding of the development of primary cilia, endosome recycling, and the immune response. Here, we review newly identified roles for the centrosome in directing membrane traffic, the immunological synapse, and the stress response.

Original languageEnglish (US)
Article numbera025049
JournalCold Spring Harbor perspectives in biology
Issue number12
StatePublished - 2016

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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