Temperament in velocardiofacial syndrome

Kevin M. Antshel, K. Stallone, N. Abdulsabur, R. Shprintzen, N. Roizen, A. M. Higgins, W. R. Kates

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


Background: Velocardiofacial syndrome (VCFS) is a microdeletion syndrome caused by a 22q11.2 chromosomal deletion. Methods: In this study, parents reported on their own temperament as well as the temperament of their child. Sixty-seven children with VCFS (mean age = 10.8, SD = 2.8; range 6-15), and age-, race- and gender-ratio matched samples of 47 community control participants (mean age = 10.4, SD = 2.6; range 6-15), and 18 sibling control participants (mean age = 12.1, SD = 1.9; range 9-15) took part in the current project. Results: Children with VCFS have a temperament that may best be described as modestly difficult; while participants with VCFS were not more difficult across all temperamental domains, children with VCFS were rated by their parents as being: (1) less regular in their daily habits (e.g. eating at the same time each day, etc.); (2) less able to focus/ sustain attention; (3) less cheerful/pleasant; (4) less likely to stay with an activity for a long time; and (5) less able to respond flexibly to changes in the environment. Conclusions: The best predictors of parent report of behavioural symptoms in children with VCFS were poor concordance between parent and child temperament across general activity level and mood domains.

Original languageEnglish (US)
Pages (from-to)218-227
Number of pages10
JournalJournal of Intellectual Disability Research
Issue number3
StatePublished - Mar 2007
Externally publishedYes


  • Developmental delay
  • Dimensions of Temperament Survey - Revised (DOTS-R)
  • Goodness of fit
  • Temperament
  • Velocardio facial syndrome (VCFS)

ASJC Scopus subject areas

  • Rehabilitation
  • Arts and Humanities (miscellaneous)
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health


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