Targeted reengineering of protein geranylgeranyltransferase type i selectivity functionally implicates active-site residues in protein-substrate recognition

Medicine & Life Sciences

• geranylgeranyltransferase type-I 100%
• Catalytic Domain 51%
• Psychology Recognition 50%
• Proteins 20%
• Farnesyltranstransferase 14%
• Prenylation 13%
• Post Translational Protein Processing 9%
• Carbon-15 8%
• p21(ras) farnesyl-protein transferase 8%
• Enzymes 7%
• Terpenes 5%
• Site-Directed Mutagenesis 5%
• Cysteine 4%
• Aptitude 3%
• Peptides 3%
• Mutation 2%

Chemical Compounds

• Prenylation 26%
• Protein 23%
• Modification 21%
• Isoprenoid 12%
• Cysteine Residue 9%
• Site-Directed Mutagenesis 9%
• Mutation 8%
• Peptide 5%
• Crystal Structure 4%