Tailoring quantum dot interfaces for improved biofunctionality and energy transfer

Joshua Zylstra, Rabeka Alam, Hyunjoo Han, Robert P. Doyle, Mathew M. Maye

Research output: Chapter in Book/Entry/PoemChapter

2 Scopus citations


Over the past decade quantum dots (qdots) have emerged as a premier biological labeling tool due to their unique photophysical properties. In order to take advantage of these properties, a lot of surface chemistry design work needs to take place due to the need of phase transfer to aqueous buffers, as well as the need to preserve both photophysical and colloidal stability. This chapter first briefly reviews a number of functionalization strategies available to researchers, and then focuses on our groups strategy. In particular, the use the amino acid L-histidine to facilitate both phase trasfer, ligand exchange, as well as direct biological functionalization. The binding mechanism and properties of the histidine-capping at the qdots is reviewed, as well as the use of resonance energy transfer (FRET and BRET) to probe the abiotic-biotic interface.

Original languageEnglish (US)
Title of host publicationFunctional Nanoparticles for Functional Nanoparticles for and Bioelectronic Devices
Subtitle of host publicationVolume 1
PublisherAmerican Chemical Society
Number of pages21
ISBN (Print)9780841227750
StatePublished - Nov 26 2012

Publication series

NameACS Symposium Series
ISSN (Print)0097-6156
ISSN (Electronic)1947-5918

ASJC Scopus subject areas

  • General Chemistry
  • General Chemical Engineering


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