Abstract
A set of synthetic approaches were developed and applied to the synthesis of eight frame-shifted farnesyl diphosphate (FPP) analogs. These analogs bear increased or decreased methylene units between the double bonds and/or diphosphate moieties of the isoprenoid structure. Evaluation versus mammalian FTase revealed that small structural changes can lead to dramatic changes in substrate ability.
Original language | English (US) |
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Pages (from-to) | 4038-4041 |
Number of pages | 4 |
Journal | Organic Letters |
Volume | 14 |
Issue number | 16 |
DOIs | |
State | Published - Aug 17 2012 |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry