Synthesis of frame-shifted farnesyl diphosphate analogs

Andrew T. Placzek, James L. Hougland, Richard A. Gibbs

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

A set of synthetic approaches were developed and applied to the synthesis of eight frame-shifted farnesyl diphosphate (FPP) analogs. These analogs bear increased or decreased methylene units between the double bonds and/or diphosphate moieties of the isoprenoid structure. Evaluation versus mammalian FTase revealed that small structural changes can lead to dramatic changes in substrate ability.

Original languageEnglish (US)
Pages (from-to)4038-4041
Number of pages4
JournalOrganic Letters
Volume14
Issue number16
DOIs
StatePublished - Aug 17 2012

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Fingerprint Dive into the research topics of 'Synthesis of frame-shifted farnesyl diphosphate analogs'. Together they form a unique fingerprint.

  • Cite this