Synthesis of antitumor ansamycins. 2. A formal synthesis of (±)-macbecin I

Simon J. Coutts; James Kallmerum

doi:10.1016/S0040-4039(00)97607-X

Synthesis of antitumor ansamycins. 2. A formal synthesis of (±)-macbecin I

Simon J. Coutts, James Kallmerum

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

18 Scopus citations

Abstract

Convergent synthesis of (±)-2 a key intermediate in the Merck synthesis of macbecin I (1.), incorporates the chelation-mediated coupling of a lithiated aryl subunit and the γ-hydroxy aldehyde equivalent 8 to establish a critical connective element of the parent ansamycin.

Original language	English (US)
Pages (from-to)	4305-4308
Number of pages	4
Journal	Tetrahedron Letters
Volume	31
Issue number	30
DOIs	https://doi.org/10.1016/S0040-4039(00)97607-X
State	Published - 1990

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

Access to Document

10.1016/S0040-4039(00)97607-X

Cite this

@article{4b90377ce8e14ffdb0b0f2f3d4de9ea6,

title = "Synthesis of antitumor ansamycins. 2. A formal synthesis of (±)-macbecin I",

abstract = "Convergent synthesis of (±)-2 a key intermediate in the Merck synthesis of macbecin I (1.), incorporates the chelation-mediated coupling of a lithiated aryl subunit and the γ-hydroxy aldehyde equivalent 8 to establish a critical connective element of the parent ansamycin.",

author = "Coutts, {Simon J.} and James Kallmerum",

year = "1990",

doi = "10.1016/S0040-4039(00)97607-X",

language = "English (US)",

volume = "31",

pages = "4305--4308",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier",

number = "30",

}

TY - JOUR

T1 - Synthesis of antitumor ansamycins. 2. A formal synthesis of (±)-macbecin I

AU - Coutts, Simon J.

AU - Kallmerum, James

PY - 1990

Y1 - 1990

N2 - Convergent synthesis of (±)-2 a key intermediate in the Merck synthesis of macbecin I (1.), incorporates the chelation-mediated coupling of a lithiated aryl subunit and the γ-hydroxy aldehyde equivalent 8 to establish a critical connective element of the parent ansamycin.

AB - Convergent synthesis of (±)-2 a key intermediate in the Merck synthesis of macbecin I (1.), incorporates the chelation-mediated coupling of a lithiated aryl subunit and the γ-hydroxy aldehyde equivalent 8 to establish a critical connective element of the parent ansamycin.

UR - http://www.scopus.com/inward/record.url?scp=0025287422&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025287422&partnerID=8YFLogxK

U2 - 10.1016/S0040-4039(00)97607-X

DO - 10.1016/S0040-4039(00)97607-X

M3 - Article

AN - SCOPUS:0025287422

SN - 0040-4039

VL - 31

SP - 4305

EP - 4308

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 30

ER -

Synthesis of antitumor ansamycins. 2. A formal synthesis of (±)-macbecin I

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this