Synthesis of antitumor ansamycins. 2. A formal synthesis of (±)-macbecin I

Simon J. Coutts, James Kallmerum

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Convergent synthesis of (±)-2 a key intermediate in the Merck synthesis of macbecin I (1.), incorporates the chelation-mediated coupling of a lithiated aryl subunit and the γ-hydroxy aldehyde equivalent 8 to establish a critical connective element of the parent ansamycin.

Original languageEnglish (US)
Pages (from-to)4305-4308
Number of pages4
JournalTetrahedron Letters
Volume31
Issue number30
DOIs
StatePublished - 1990

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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