Synthesis of antitumor ansamycins. 1. Serial sigmatropic construction of the C11-C21 ansa subunit of macbecin I

Simon J. Couus; Mark D. Wiuman; James Kallmerten

doi:10.1016/S0040-4039(00)97606-8

Synthesis of antitumor ansamycins. 1. Serial sigmatropic construction of the C₁₁-C₂₁ ansa subunit of macbecin I

Simon J. Couus, Mark D. Wiuman, James Kallmerten

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

Diol 4. comprising the C₁₁-C₂₁ ansa subunit of the antitumor antibiotic macbecin I has been prepared by a sequence incorporating sequential [2,3] Wittig rearrangements to establish the carbon skeleton and remote functionality of the macbecin ansa system.

Original language	English (US)
Pages (from-to)	4301-4304
Number of pages	4
Journal	Tetrahedron Letters
Volume	31
Issue number	30
DOIs	https://doi.org/10.1016/S0040-4039(00)97606-8
State	Published - 1990

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4039(00)97606-8

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title = "Synthesis of antitumor ansamycins. 1. Serial sigmatropic construction of the C11-C21 ansa subunit of macbecin I",

abstract = "Diol 4. comprising the C11-C21 ansa subunit of the antitumor antibiotic macbecin I has been prepared by a sequence incorporating sequential [2,3] Wittig rearrangements to establish the carbon skeleton and remote functionality of the macbecin ansa system.",

author = "Couus, {Simon J.} and Wiuman, {Mark D.} and James Kallmerten",

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doi = "10.1016/S0040-4039(00)97606-8",

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T1 - Synthesis of antitumor ansamycins. 1. Serial sigmatropic construction of the C11-C21 ansa subunit of macbecin I

AU - Couus, Simon J.

AU - Wiuman, Mark D.

AU - Kallmerten, James

PY - 1990

Y1 - 1990

N2 - Diol 4. comprising the C11-C21 ansa subunit of the antitumor antibiotic macbecin I has been prepared by a sequence incorporating sequential [2,3] Wittig rearrangements to establish the carbon skeleton and remote functionality of the macbecin ansa system.

AB - Diol 4. comprising the C11-C21 ansa subunit of the antitumor antibiotic macbecin I has been prepared by a sequence incorporating sequential [2,3] Wittig rearrangements to establish the carbon skeleton and remote functionality of the macbecin ansa system.

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U2 - 10.1016/S0040-4039(00)97606-8

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SN - 0040-4039

VL - 31

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Synthesis of antitumor ansamycins. 1. Serial sigmatropic construction of the C₁₁-C₂₁ ansa subunit of macbecin I

Abstract

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