Synthesis of antitumor ansamycins. 1. Serial sigmatropic construction of the C11-C21 ansa subunit of macbecin I

Simon J. Couus, Mark D. Wiuman, James Kallmerten

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

Diol 4. comprising the C11-C21 ansa subunit of the antitumor antibiotic macbecin I has been prepared by a sequence incorporating sequential [2,3] Wittig rearrangements to establish the carbon skeleton and remote functionality of the macbecin ansa system.

Original languageEnglish (US)
Pages (from-to)4301-4304
Number of pages4
JournalTetrahedron Letters
Volume31
Issue number30
DOIs
StatePublished - 1990

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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