Synthesis of 2-amino-imidazo[4,5-b]pyridines

Adam J. Rosenberg; Theresa M. Williams; Abraham J. Jordan; Daniel A. Clark

doi:10.1039/c3ob40413g

Synthesis of 2-amino-imidazo[4,5-b]pyridines

Adam J. Rosenberg, Theresa M. Williams, Abraham J. Jordan, Daniel A. Clark

Department of Chemistry

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

The C2 amination of imidazo[4,5-b]pyridines was accomplished through C2 halogenation followed by substitution (S_NAr) with functionalized primary and secondary amines. This regioselective sequence is operationally simple and provides an easy access to derivatives of protected imidazo[4,5-b]pyridines.

Original language	English (US)
Pages (from-to)	3064-3072
Number of pages	9
Journal	Organic and Biomolecular Chemistry
Volume	11
Issue number	18
DOIs	https://doi.org/10.1039/c3ob40413g
State	Published - May 14 2013

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

Access to Document

10.1039/c3ob40413g

Cite this

@article{d30e7d9326e5452c9dc6041fb96d1e6f,

title = "Synthesis of 2-amino-imidazo[4,5-b]pyridines",

abstract = "The C2 amination of imidazo[4,5-b]pyridines was accomplished through C2 halogenation followed by substitution (SNAr) with functionalized primary and secondary amines. This regioselective sequence is operationally simple and provides an easy access to derivatives of protected imidazo[4,5-b]pyridines.",

author = "Rosenberg, {Adam J.} and Williams, {Theresa M.} and Jordan, {Abraham J.} and Clark, {Daniel A.}",

year = "2013",

month = may,

day = "14",

doi = "10.1039/c3ob40413g",

language = "English (US)",

volume = "11",

pages = "3064--3072",

journal = "Organic and Biomolecular Chemistry",

issn = "1477-0520",

publisher = "Royal Society of Chemistry",

number = "18",

}

TY - JOUR

T1 - Synthesis of 2-amino-imidazo[4,5-b]pyridines

AU - Rosenberg, Adam J.

AU - Williams, Theresa M.

AU - Jordan, Abraham J.

AU - Clark, Daniel A.

PY - 2013/5/14

Y1 - 2013/5/14

N2 - The C2 amination of imidazo[4,5-b]pyridines was accomplished through C2 halogenation followed by substitution (SNAr) with functionalized primary and secondary amines. This regioselective sequence is operationally simple and provides an easy access to derivatives of protected imidazo[4,5-b]pyridines.

AB - The C2 amination of imidazo[4,5-b]pyridines was accomplished through C2 halogenation followed by substitution (SNAr) with functionalized primary and secondary amines. This regioselective sequence is operationally simple and provides an easy access to derivatives of protected imidazo[4,5-b]pyridines.

UR - http://www.scopus.com/inward/record.url?scp=84879469764&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84879469764&partnerID=8YFLogxK

U2 - 10.1039/c3ob40413g

DO - 10.1039/c3ob40413g

M3 - Article

C2 - 23535944

AN - SCOPUS:84879469764

SN - 1477-0520

VL - 11

SP - 3064

EP - 3072

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 18

ER -

Synthesis of 2-amino-imidazo[4,5-b]pyridines

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this