Synthesis of 2-amino-imidazo[4,5-b]pyridines

Adam J. Rosenberg, Theresa M. Williams, Abraham J. Jordan, Daniel A. Clark

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

The C2 amination of imidazo[4,5-b]pyridines was accomplished through C2 halogenation followed by substitution (SNAr) with functionalized primary and secondary amines. This regioselective sequence is operationally simple and provides an easy access to derivatives of protected imidazo[4,5-b]pyridines.

Original languageEnglish (US)
Pages (from-to)3064-3072
Number of pages9
JournalOrganic and Biomolecular Chemistry
Volume11
Issue number18
DOIs
StatePublished - May 14 2013

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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  • Cite this

    Rosenberg, A. J., Williams, T. M., Jordan, A. J., & Clark, D. A. (2013). Synthesis of 2-amino-imidazo[4,5-b]pyridines. Organic and Biomolecular Chemistry, 11(18), 3064-3072. https://doi.org/10.1039/c3ob40413g