Synthesis of 2-amino-imidazo[4,5-b]pyridines

Adam J. Rosenberg, Theresa M. Williams, Abraham J. Jordan, Daniel A. Clark

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The C2 amination of imidazo[4,5-b]pyridines was accomplished through C2 halogenation followed by substitution (SNAr) with functionalized primary and secondary amines. This regioselective sequence is operationally simple and provides an easy access to derivatives of protected imidazo[4,5-b]pyridines.

Original languageEnglish (US)
Pages (from-to)3064-3072
Number of pages9
JournalOrganic and Biomolecular Chemistry
Volume11
Issue number18
DOIs
StatePublished - May 14 2013

Fingerprint

pyridines
Halogenation
halogenation
Amination
synthesis
Amines
amines
Substitution reactions
substitutes
Derivatives
imidazo(4,5-b)pyridine

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Biochemistry

Cite this

Rosenberg, A. J., Williams, T. M., Jordan, A. J., & Clark, D. A. (2013). Synthesis of 2-amino-imidazo[4,5-b]pyridines. Organic and Biomolecular Chemistry, 11(18), 3064-3072. https://doi.org/10.1039/c3ob40413g

Synthesis of 2-amino-imidazo[4,5-b]pyridines. / Rosenberg, Adam J.; Williams, Theresa M.; Jordan, Abraham J.; Clark, Daniel A.

In: Organic and Biomolecular Chemistry, Vol. 11, No. 18, 14.05.2013, p. 3064-3072.

Research output: Contribution to journalArticle

Rosenberg, AJ, Williams, TM, Jordan, AJ & Clark, DA 2013, 'Synthesis of 2-amino-imidazo[4,5-b]pyridines', Organic and Biomolecular Chemistry, vol. 11, no. 18, pp. 3064-3072. https://doi.org/10.1039/c3ob40413g
Rosenberg AJ, Williams TM, Jordan AJ, Clark DA. Synthesis of 2-amino-imidazo[4,5-b]pyridines. Organic and Biomolecular Chemistry. 2013 May 14;11(18):3064-3072. https://doi.org/10.1039/c3ob40413g
Rosenberg, Adam J. ; Williams, Theresa M. ; Jordan, Abraham J. ; Clark, Daniel A. / Synthesis of 2-amino-imidazo[4,5-b]pyridines. In: Organic and Biomolecular Chemistry. 2013 ; Vol. 11, No. 18. pp. 3064-3072.
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