Abstract
Clearing the way: Glucagon-like peptide-1 (GLP-1) receptor agonists are proving a potent weapon in the treatment of typeII diabetes. A new vitaminB12-GLP-1 conjugate is investigated and shown to have insulinotropic properties similar to the unmodified peptide. These results are critical to the exploitation of the vitaminB12 oral uptake pathway for peptide delivery.
Original language | English (US) |
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Pages (from-to) | 582-586 |
Number of pages | 5 |
Journal | ChemMedChem |
Volume | 8 |
Issue number | 4 |
DOIs | |
State | Published - Apr 2013 |
Keywords
- Glucagon-like peptide-1 (GLP-1)
- Human pancreatic islets
- Insulinotropic effects
- Receptor agonists
- VitaminB
ASJC Scopus subject areas
- Drug Discovery
- General Pharmacology, Toxicology and Pharmaceutics
- Molecular Medicine
- Biochemistry
- Pharmacology
- Organic Chemistry