Synthesis, Characterization and Pharmacodynamics of Vitamin-B12-Conjugated Glucagon-Like Peptide-1

Susan Clardy-James, Oleg G. Chepurny, Colin A. Leech, George G. Holz, Robert P. Doyle

Research output: Contribution to journalArticlepeer-review

30 Scopus citations


Clearing the way: Glucagon-like peptide-1 (GLP-1) receptor agonists are proving a potent weapon in the treatment of typeII diabetes. A new vitaminB12-GLP-1 conjugate is investigated and shown to have insulinotropic properties similar to the unmodified peptide. These results are critical to the exploitation of the vitaminB12 oral uptake pathway for peptide delivery.

Original languageEnglish (US)
Pages (from-to)582-586
Number of pages5
Issue number4
StatePublished - Apr 2013


  • Glucagon-like peptide-1 (GLP-1)
  • Human pancreatic islets
  • Insulinotropic effects
  • Receptor agonists
  • VitaminB

ASJC Scopus subject areas

  • Drug Discovery
  • General Pharmacology, Toxicology and Pharmaceutics
  • Molecular Medicine
  • Biochemistry
  • Pharmacology
  • Organic Chemistry


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