Synthesis, Characterization and Pharmacodynamics of Vitamin-B12-Conjugated Glucagon-Like Peptide-1

Susan Clardy-James, Oleg G. Chepurny, Colin A. Leech, George G. Holz, Robert P. Doyle

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

Clearing the way: Glucagon-like peptide-1 (GLP-1) receptor agonists are proving a potent weapon in the treatment of typeII diabetes. A new vitaminB12-GLP-1 conjugate is investigated and shown to have insulinotropic properties similar to the unmodified peptide. These results are critical to the exploitation of the vitaminB12 oral uptake pathway for peptide delivery.

Original languageEnglish (US)
Pages (from-to)582-586
Number of pages5
JournalChemMedChem
Volume8
Issue number4
DOIs
StatePublished - Apr 2013

Keywords

  • Glucagon-like peptide-1 (GLP-1)
  • Human pancreatic islets
  • Insulinotropic effects
  • Receptor agonists
  • VitaminB

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Organic Chemistry

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