Synthesis, Characterization and Pharmacodynamics of Vitamin-B12-Conjugated Glucagon-Like Peptide-1

Susan Clardy-James, Oleg G. Chepurny, Colin A. Leech, George G. Holz, Robert Patrick Doyle

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Clearing the way: Glucagon-like peptide-1 (GLP-1) receptor agonists are proving a potent weapon in the treatment of typeII diabetes. A new vitaminB12-GLP-1 conjugate is investigated and shown to have insulinotropic properties similar to the unmodified peptide. These results are critical to the exploitation of the vitaminB12 oral uptake pathway for peptide delivery.

Original languageEnglish (US)
Pages (from-to)582-586
Number of pages5
JournalChemMedChem
Volume8
Issue number4
DOIs
StatePublished - Apr 2013

Fingerprint

Pharmacodynamics
Glucagon-Like Peptide 1
Vitamin B 12
Peptides
Weapons
Medical problems
Glucagon-Like Peptide-1 Receptor

Keywords

  • Glucagon-like peptide-1 (GLP-1)
  • Human pancreatic islets
  • Insulinotropic effects
  • Receptor agonists
  • VitaminB

ASJC Scopus subject areas

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Organic Chemistry
  • Molecular Medicine

Cite this

Synthesis, Characterization and Pharmacodynamics of Vitamin-B12-Conjugated Glucagon-Like Peptide-1. / Clardy-James, Susan; Chepurny, Oleg G.; Leech, Colin A.; Holz, George G.; Doyle, Robert Patrick.

In: ChemMedChem, Vol. 8, No. 4, 04.2013, p. 582-586.

Research output: Contribution to journalArticle

Clardy-James, Susan ; Chepurny, Oleg G. ; Leech, Colin A. ; Holz, George G. ; Doyle, Robert Patrick. / Synthesis, Characterization and Pharmacodynamics of Vitamin-B12-Conjugated Glucagon-Like Peptide-1. In: ChemMedChem. 2013 ; Vol. 8, No. 4. pp. 582-586.
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