Synthesis, Characterization, and Cellular Uptake of Magnesium Maltol and Ethylmaltol Complexes

Derek R. Case, Ren Gonzalez, Jon Zubieta, Robert P. Doyle

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Magnesium deficiency and/or deficit (hypomagnesemia, <0.75 mmol/L in the blood) has become a recognized problem in healthcare and clinical settings. Concomitantly, supplementation has become recognized as the primary means of mitigating such deficiencies. Common magnesium supplements typically suffer from shortcomings: rapid dissociation and subsequent laxation (magnesium salts: e.g., magnesium chloride), poor water solubility (magnesium oxides and hydroxides), poor characterizability (magnesium chelates), and are/or use of non-natural ligands. To this end, there is a need for the development of fully characterized, water-soluble, all-natural magnesium compounds. Herein, we discuss the synthesis, solution and solid-state characterization, aqueous solubility, and cellular uptake of magnesium complexes of maltol and ethylmaltol, ligands whose magnesium complexes have yet to be fully explored.

Original languageEnglish (US)
Pages (from-to)29713-29723
Number of pages11
JournalACS Omega
Issue number44
StatePublished - Nov 9 2021

ASJC Scopus subject areas

  • General Chemistry
  • General Chemical Engineering


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