Synthesis, Characterization, and Cellular Uptake of a Glycylglycine Chelate of Magnesium

Derek R. Case, Ren Gonzalez, Jon Zubieta, Robert P. Doyle

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Human chronic latent magnesium deficiency is estimated to impact a substantive portion of the world's population. A number of magnesium compounds have been developed to combat this deficiency; however, none are ideal due to issues of solubility, absorption, side effects (e.g., laxation) and/or formulation. Here, we describe the pH-dependent synthesis, chemical characterization (inductively coupled plasma and thermal analysis, infrared and nuclear magnetic resonance (1D and 2D) spectroscopies, and electrospray mass spectrometry) and in vitro uptake (in a cell model of the large intestine (CaCo-2 cells)) of a magnesium complex of the glycine dimer (HG2). Results demonstrate that the HG2 ligand assumes a tridentate coordination mode with an N2O donor set and an octahedral coordination sphere completed with coordinated waters. The magnesium:HG2 complex exhibits significant solubility and cellular uptake.

Original languageEnglish (US)
Pages (from-to)33454-33461
Number of pages8
JournalACS Omega
Issue number49
StatePublished - Dec 14 2021

ASJC Scopus subject areas

  • General Chemistry
  • General Chemical Engineering


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