Synthesis, Characterization, and Cellular Uptake of a Glycylglycine Chelate of Magnesium

Derek R. Case, Ren Gonzalez, Jon Zubieta, Robert P. Doyle

Research output: Contribution to journalArticlepeer-review

Abstract

Human chronic latent magnesium deficiency is estimated to impact a substantive portion of the world's population. A number of magnesium compounds have been developed to combat this deficiency; however, none are ideal due to issues of solubility, absorption, side effects (e.g., laxation) and/or formulation. Here, we describe the pH-dependent synthesis, chemical characterization (inductively coupled plasma and thermal analysis, infrared and nuclear magnetic resonance (1D and 2D) spectroscopies, and electrospray mass spectrometry) and in vitro uptake (in a cell model of the large intestine (CaCo-2 cells)) of a magnesium complex of the glycine dimer (HG2). Results demonstrate that the HG2 ligand assumes a tridentate coordination mode with an N2O donor set and an octahedral coordination sphere completed with coordinated waters. The magnesium:HG2 complex exhibits significant solubility and cellular uptake.

Original languageEnglish (US)
Pages (from-to)33454-33461
Number of pages8
JournalACS Omega
Volume6
Issue number49
DOIs
StatePublished - Dec 14 2021

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)

Fingerprint

Dive into the research topics of 'Synthesis, Characterization, and Cellular Uptake of a Glycylglycine Chelate of Magnesium'. Together they form a unique fingerprint.

Cite this