Synthesis and chemical and biological evaluation of a glycine tripeptide chelate of magnesium

Derek R. Case; Jon Zubieta; Ren Gonzalez; Robert P. Doyle

doi:10.3390/molecules26092419

Synthesis and chemical and biological evaluation of a glycine tripeptide chelate of magnesium

Derek R. Case, Jon Zubieta, Ren Gonzalez, Robert P. Doyle

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

Magnesium (Mg²⁺) plays a crucial role in over 80% of all metabolic functions. It is becoming increasingly apparent that magnesium deficiency (hypomagnesemia) may play an important role in chronic disease. To counteract magnesium deficiency, there is an unmet clinical need to develop new fully characterized, highly bioavailable, and substantially water-soluble magnesium supplements. To this end, triglycine (HG₃ ), a tripeptide of the amino acid glycine, was chosen as a chelating ligand for magnesium, given its natural occurrence and water solubility, and entropically-driven metal binding. Herein, we discuss the synthesis, chemical and physical characterization, and cellular uptake of a magnesium triglycine chelate (MgG₃), an octahedral complex with extraordinary water solubility and improved cellular uptake in CaCo-2 cells than select commonly used magnesium supplements.

Original language	English (US)
Article number	2419
Journal	Molecules
Volume	26
Issue number	9
DOIs	https://doi.org/10.3390/molecules26092419
State	Published - Apr 21 2021

Keywords

Amino acid chelate
CaCo-2 cells
Magnesium
Solubility
Triglycine

ASJC Scopus subject areas

Analytical Chemistry
Chemistry (miscellaneous)
Molecular Medicine
Pharmaceutical Science
Drug Discovery
Physical and Theoretical Chemistry
Organic Chemistry

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10.3390/molecules26092419

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title = "Synthesis and chemical and biological evaluation of a glycine tripeptide chelate of magnesium",

abstract = "Magnesium (Mg2+) plays a crucial role in over 80% of all metabolic functions. It is becoming increasingly apparent that magnesium deficiency (hypomagnesemia) may play an important role in chronic disease. To counteract magnesium deficiency, there is an unmet clinical need to develop new fully characterized, highly bioavailable, and substantially water-soluble magnesium supplements. To this end, triglycine (HG3 ), a tripeptide of the amino acid glycine, was chosen as a chelating ligand for magnesium, given its natural occurrence and water solubility, and entropically-driven metal binding. Herein, we discuss the synthesis, chemical and physical characterization, and cellular uptake of a magnesium triglycine chelate (MgG3), an octahedral complex with extraordinary water solubility and improved cellular uptake in CaCo-2 cells than select commonly used magnesium supplements.",

keywords = "Amino acid chelate, CaCo-2 cells, Magnesium, Solubility, Triglycine",

author = "Case, {Derek R.} and Jon Zubieta and Ren Gonzalez and Doyle, {Robert P.}",

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AU - Case, Derek R.

AU - Zubieta, Jon

AU - Gonzalez, Ren

AU - Doyle, Robert P.

PY - 2021/4/21

Y1 - 2021/4/21

N2 - Magnesium (Mg2+) plays a crucial role in over 80% of all metabolic functions. It is becoming increasingly apparent that magnesium deficiency (hypomagnesemia) may play an important role in chronic disease. To counteract magnesium deficiency, there is an unmet clinical need to develop new fully characterized, highly bioavailable, and substantially water-soluble magnesium supplements. To this end, triglycine (HG3 ), a tripeptide of the amino acid glycine, was chosen as a chelating ligand for magnesium, given its natural occurrence and water solubility, and entropically-driven metal binding. Herein, we discuss the synthesis, chemical and physical characterization, and cellular uptake of a magnesium triglycine chelate (MgG3), an octahedral complex with extraordinary water solubility and improved cellular uptake in CaCo-2 cells than select commonly used magnesium supplements.

AB - Magnesium (Mg2+) plays a crucial role in over 80% of all metabolic functions. It is becoming increasingly apparent that magnesium deficiency (hypomagnesemia) may play an important role in chronic disease. To counteract magnesium deficiency, there is an unmet clinical need to develop new fully characterized, highly bioavailable, and substantially water-soluble magnesium supplements. To this end, triglycine (HG3 ), a tripeptide of the amino acid glycine, was chosen as a chelating ligand for magnesium, given its natural occurrence and water solubility, and entropically-driven metal binding. Herein, we discuss the synthesis, chemical and physical characterization, and cellular uptake of a magnesium triglycine chelate (MgG3), an octahedral complex with extraordinary water solubility and improved cellular uptake in CaCo-2 cells than select commonly used magnesium supplements.

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KW - Magnesium

KW - Solubility

KW - Triglycine

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Synthesis and chemical and biological evaluation of a glycine tripeptide chelate of magnesium

Abstract

Keywords

ASJC Scopus subject areas

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