Synthesis and characterization of complexes of the {ReO}3+ core with SNS and S donor ligands

Frank J. Femia, Xiaoyuan Chen, Kevin P. Maresca, Timothy M. Shoup, John W. Babich, Jon Zubieta

Research output: Contribution to journalArticle

21 Scopus citations

Abstract

The reaction of [ReOCl3(PPh3)2] with N,N-bis(2-mercaptoethyl)benzylamine and 4-bromobenzenethiol allowed for the isolation of [ReO{η3-(SCH2CH2)2N(CH2C6H5)}-(η1 I-C6H4Br-4-S)] (1). The reaction of [ReOCL3(PPh3)2] with [(HSCH2CH2)2N(CH2C5H4N)] and the appropriate thiol in chloroform treated with triethylamine has led to the isolation of a series of neutral rhenium complexes of the type [ReO{η3-(SCH2CH2)2N(CH2C5H4N)}(η1-C6H4X-4-S)] (X=Br (2), Cl (3), F (4), and OCH3 (5)) and [ReO{η3-(SCH2CH2)2N(CH2C5H4N)}(η1-C6H4OCH3-4-CH2S)] (6). Likewise, under similar reaction conditions, the use of the related tridentate ligand, [(HSCH2CH2)2N(CH2CH2C5H4N)], has led to the isolation of a series of rhenium complexes of the type [ReO{η3-(SCH2CH2)2N(CH2CH2C5H4N)}(η<1-C6H4X-4-S)] (X=Br (7), Cl (8), OCH3 (9)), as well as [ReO{η3-(SCH2CH2)2N(CH2CH2C5H4N)}(η1-C6H4C1-4-CH2S)]·0.5CH3 (CH2)4CH3 (10). These compounds are extensions of the '3 + 1' approach to the synthesis of materials with the {MO}3+ core (M = Tc and Re), which have applications in nuclear medicine. The ligands chosen allow systematic exploration of the consequences of para-substitution on the monodentate thiolate ligand [S] and of derivatization of the substituent R on the tridentate aminodithiol ligand [SNS] of the type (HSCH2CH2)2NR. Such modifications can influence lipophilicity, charge, size and molecular weight of the complex and consequently the biodistribution. (C) 2000 Elsevier Science S.A.

Original languageEnglish (US)
Pages (from-to)30-37
Number of pages8
JournalInorganica Chimica Acta
Volume306
Issue number1
DOIs
StatePublished - Aug 11 2000

Keywords

  • Crystal structure
  • Oxo complexes
  • Rhenium complexes
  • S-donor ligand complexes
  • SNS-donor ligand complexes

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Inorganic Chemistry
  • Materials Chemistry

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