Synergistic Interactions Are Prevalent in Catalytic Amyloids

Liam R. Marshall, Megha Jayachandran, Zsofia Lengyel-Zhand, Caroline M. Rufo, Austin Kriews, Min Chul Kim, Ivan V. Korendovych

Research output: Contribution to journalArticle

Abstract

Interactions between multiple functional groups are key to catalysis. Previously, we reported synergistic interactions in catalytic amyloids formed by mixtures of heptameric peptides that lead to significant improvements in esterase activity. Herein, we describe the in-depth investigation of synergistic interactions within a family of amyloid fibrils, exploring the results of functional group interactions, the effects of chirality and the use of mixed enantiomers within fibrils. Remarkably, we find that synergistic interactions (either positive or negative) are found in the vast majority of binary mixtures of catalytic amyloid-forming peptides. The productive arrangements of functionalities rapidly identified by mixing different peptides will undoubtedly lead to the development of more active catalysts for a variety of different transformations.

Original languageEnglish (US)
Pages (from-to)2611-2614
Number of pages4
JournalChemBioChem
Volume21
Issue number18
DOIs
StatePublished - Sep 14 2020

Keywords

  • amyloids
  • catalysis
  • peptides
  • self-assembly
  • synergistic interactions

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Organic Chemistry

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  • Cite this

    Marshall, L. R., Jayachandran, M., Lengyel-Zhand, Z., Rufo, C. M., Kriews, A., Kim, M. C., & Korendovych, I. V. (2020). Synergistic Interactions Are Prevalent in Catalytic Amyloids. ChemBioChem, 21(18), 2611-2614. https://doi.org/10.1002/cbic.202000205