TY - GEN
T1 - Surface shape memory substrates for active cell culture
AU - Davis, K. A.
AU - Burke, K. A.
AU - Mather, P. T.
AU - Henderson, J. H.
PY - 2011
Y1 - 2011
N2 - Shape memory polymer (SMP) substrates compatible with cell culture are presented that undergo programmed changes in surface topography on command to direct cell behavior. SMPs are a class of active materials that can be programmed to transition from a stable temporary shape to a permanent shape by a triggering mechanism, such as heat. Here, an SMP surface topography was programmed to transition from parallel micron-scale grooves to a flat surface. C3H/10T1/2 cells were allowed to adhere and spread on the temporary topography at 30°C. Topographic transition was then triggered by transfer to 37°C. Changes in substrate topography were found to direct cell behavior, as assessed by analysis of cell alignment, while high cell viability was maintained. This first example of active cell culture substrates should have great potential in the design of unique approaches for advanced investigation of mechanotransduction and cell biomechanical function and softmatter physics.
AB - Shape memory polymer (SMP) substrates compatible with cell culture are presented that undergo programmed changes in surface topography on command to direct cell behavior. SMPs are a class of active materials that can be programmed to transition from a stable temporary shape to a permanent shape by a triggering mechanism, such as heat. Here, an SMP surface topography was programmed to transition from parallel micron-scale grooves to a flat surface. C3H/10T1/2 cells were allowed to adhere and spread on the temporary topography at 30°C. Topographic transition was then triggered by transfer to 37°C. Changes in substrate topography were found to direct cell behavior, as assessed by analysis of cell alignment, while high cell viability was maintained. This first example of active cell culture substrates should have great potential in the design of unique approaches for advanced investigation of mechanotransduction and cell biomechanical function and softmatter physics.
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U2 - 10.1109/NEBC.2011.5778692
DO - 10.1109/NEBC.2011.5778692
M3 - Conference contribution
AN - SCOPUS:79958761998
SN - 9781612848273
T3 - 2011 IEEE 37th Annual Northeast Bioengineering Conference, NEBEC 2011
BT - 2011 IEEE 37th Annual Northeast Bioengineering Conference, NEBEC 2011
T2 - 37th Annual Northeast Bioengineering Conference, NEBEC 2011
Y2 - 1 April 2011 through 3 April 2011
ER -