Surface control of blastospore attachment and ligand-mediated hyphae adhesion of Candida albicans

Nisha Varghese, Sijie Yang, Preeti Sejwal, Yan Yeung Luk

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Adhesion on a surface via nonspecific attachment or multiple ligand-receptor interactions is a critical event for fungal infection by Candida albicans. Here, we find that the tri(ethylene glycol)- and d-mannitol-terminated monolayers do not resist the blastospore attachment, but prevent the hyphae adhesion of C. albicans. The hyphae adhesion can be facilitated by tripeptide sequences of arginine-glycine-aspartic acid (RGD) covalently decorated on a background of tri(ethylene glycol)-terminated monolayers. This adhesion mediated by selected ligands is sensitive to the scrambling of peptide sequences, and is inhibited by the presence of cyclic RGD peptides in the solution.

Original languageEnglish (US)
Pages (from-to)10418-10420
Number of pages3
JournalChemical Communications
Volume49
Issue number88
DOIs
StatePublished - Oct 10 2013

ASJC Scopus subject areas

  • Catalysis
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Chemistry(all)
  • Surfaces, Coatings and Films
  • Metals and Alloys
  • Materials Chemistry

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