Surface control of blastospore attachment and ligand-mediated hyphae adhesion of Candida albicans

Nisha Varghese; Sijie Yang; Preeti Sejwal; Yan Yeung Luk

doi:10.1039/c3cc45945d

Surface control of blastospore attachment and ligand-mediated hyphae adhesion of Candida albicans

Nisha Varghese, Sijie Yang, Preeti Sejwal, Yan Yeung Luk

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Adhesion on a surface via nonspecific attachment or multiple ligand-receptor interactions is a critical event for fungal infection by Candida albicans. Here, we find that the tri(ethylene glycol)- and d-mannitol-terminated monolayers do not resist the blastospore attachment, but prevent the hyphae adhesion of C. albicans. The hyphae adhesion can be facilitated by tripeptide sequences of arginine-glycine-aspartic acid (RGD) covalently decorated on a background of tri(ethylene glycol)-terminated monolayers. This adhesion mediated by selected ligands is sensitive to the scrambling of peptide sequences, and is inhibited by the presence of cyclic RGD peptides in the solution.

Original language	English (US)
Pages (from-to)	10418-10420
Number of pages	3
Journal	Chemical Communications
Volume	49
Issue number	88
DOIs	https://doi.org/10.1039/c3cc45945d
State	Published - Oct 10 2013

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
General Chemistry
Ceramics and Composites
Metals and Alloys
Materials Chemistry
Surfaces, Coatings and Films
Catalysis

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abstract = "Adhesion on a surface via nonspecific attachment or multiple ligand-receptor interactions is a critical event for fungal infection by Candida albicans. Here, we find that the tri(ethylene glycol)- and d-mannitol-terminated monolayers do not resist the blastospore attachment, but prevent the hyphae adhesion of C. albicans. The hyphae adhesion can be facilitated by tripeptide sequences of arginine-glycine-aspartic acid (RGD) covalently decorated on a background of tri(ethylene glycol)-terminated monolayers. This adhesion mediated by selected ligands is sensitive to the scrambling of peptide sequences, and is inhibited by the presence of cyclic RGD peptides in the solution.",

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AU - Varghese, Nisha

AU - Yang, Sijie

AU - Sejwal, Preeti

AU - Luk, Yan Yeung

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Y1 - 2013/10/10

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AB - Adhesion on a surface via nonspecific attachment or multiple ligand-receptor interactions is a critical event for fungal infection by Candida albicans. Here, we find that the tri(ethylene glycol)- and d-mannitol-terminated monolayers do not resist the blastospore attachment, but prevent the hyphae adhesion of C. albicans. The hyphae adhesion can be facilitated by tripeptide sequences of arginine-glycine-aspartic acid (RGD) covalently decorated on a background of tri(ethylene glycol)-terminated monolayers. This adhesion mediated by selected ligands is sensitive to the scrambling of peptide sequences, and is inhibited by the presence of cyclic RGD peptides in the solution.

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Surface control of blastospore attachment and ligand-mediated hyphae adhesion of Candida albicans

Abstract

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