Surface control of blastospore attachment and ligand-mediated hyphae adhesion of Candida albicans

Nisha Varghese, Sijie Yang, Preeti Sejwal, Yan Yeung Luk

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Adhesion on a surface via nonspecific attachment or multiple ligand-receptor interactions is a critical event for fungal infection by Candida albicans. Here, we find that the tri(ethylene glycol)- and d-mannitol- terminated monolayers do not resist the blastospore attachment, but prevent the hyphae adhesion of C. albicans. The hyphae adhesion can be facilitated by tripeptide sequences of arginine-glycine-aspartic acid (RGD) covalently decorated on a background of tri(ethylene glycol)-terminated monolayers. This adhesion mediated by selected ligands is sensitive to the scrambling of peptide sequences, and is inhibited by the presence of cyclic RGD peptides in the solution.

Original languageEnglish (US)
Pages (from-to)10418-10420
Number of pages3
JournalChemical Communications
Volume49
Issue number88
DOIs
StatePublished - Nov 14 2013

Fingerprint

Control surfaces
Candida
Adhesion
Ligands
Ethylene Glycol
Ethylene glycol
Monolayers
Arginine
Mannitol
Aspartic Acid
Glycine
Peptides
Amino acids
Acids

ASJC Scopus subject areas

  • Metals and Alloys
  • Materials Chemistry
  • Surfaces, Coatings and Films
  • Electronic, Optical and Magnetic Materials
  • Ceramics and Composites
  • Catalysis
  • Chemistry(all)

Cite this

Surface control of blastospore attachment and ligand-mediated hyphae adhesion of Candida albicans. / Varghese, Nisha; Yang, Sijie; Sejwal, Preeti; Luk, Yan Yeung.

In: Chemical Communications, Vol. 49, No. 88, 14.11.2013, p. 10418-10420.

Research output: Contribution to journalArticle

Varghese, Nisha ; Yang, Sijie ; Sejwal, Preeti ; Luk, Yan Yeung. / Surface control of blastospore attachment and ligand-mediated hyphae adhesion of Candida albicans. In: Chemical Communications. 2013 ; Vol. 49, No. 88. pp. 10418-10420.
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